Sputum eosinophil counts predict asthma control after discontinuation of inhaled corticosteroids
A Deykin, SC Lazarus, JV Fahy, ME Wechsler… - Journal of allergy and …, 2005 - Elsevier
BACKGROUND: Although inhaled corticosteroids (ICSs) are effective in preventing
deterioration in asthma control, at least half of subjects with mild-to-moderate asthma will …
deterioration in asthma control, at least half of subjects with mild-to-moderate asthma will …
Loss of control of asthma following inhaled corticosteroid withdrawal is associated with increased sputum interleukin-8 and neutrophils
K Maneechotesuwan, S Essilfie-Quaye, SA Kharitonov… - Chest, 2007 - Elsevier
Background: The role of neutrophils in exacerbations of asthma is poorly understood. We
examined the effect of withdrawal of inhaled corticosteroids on sputum inflammatory indexes …
examined the effect of withdrawal of inhaled corticosteroids on sputum inflammatory indexes …
Relationship of inhaled corticosteroid adherence to asthma exacerbations in patients with moderate-to-severe asthma
A Papi, D Ryan, JB Soriano, H Chrystyn… - The Journal of Allergy …, 2018 - Elsevier
Background Patients with asthma and elevated blood eosinophils are at increased risk of
severe exacerbations. Management of these patients should consider nonadherence to …
severe exacerbations. Management of these patients should consider nonadherence to …
Predictive markers of asthma exacerbation during stepwise dose reduction of inhaled corticosteroids
JD Leuppi, CM Salome, CR Jenkins… - American journal of …, 2001 - atsjournals.org
To determine predictors for failed reduction of inhaled corticosteroids (ICS), in 50 subjects
with well-controlled asthma (age 43.7 [18–69]; 22 males) taking a median dose of 1,000 μ g …
with well-controlled asthma (age 43.7 [18–69]; 22 males) taking a median dose of 1,000 μ g …
The predicting response to inhaled corticosteroid efficacy (PRICE) trial
RJ Martin, SJ Szefler, TS King, M Kraft… - Journal of allergy and …, 2007 - Elsevier
BACKGROUND: Although guidelines recommend anti-inflammatory therapy for persistent
asthma, recent studies suggest that 25% to 35% of patients with asthma may not improve …
asthma, recent studies suggest that 25% to 35% of patients with asthma may not improve …
Predictors of loss of asthma control induced by corticosteroid withdrawal
J Belda, K Parameswaran, C Lemière… - Canadian respiratory …, 2006 - Wiley Online Library
BACKGROUND: Asthma guidelines recommend reducing the dose of inhaled
corticosteroids after establishing control. OBJECTIVE: To identify predictors of loss of control …
corticosteroids after establishing control. OBJECTIVE: To identify predictors of loss of control …
Effectiveness of inhaled corticosteroids in real life on clinical outcomes, sputum cells and systemic inflammation in asthmatics: a retrospective cohort study in a …
SF Demarche, FN Schleich, MA Henket, VA Paulus… - BMJ open, 2017 - bmjopen.bmj.com
Objectives The impact of inhaled corticosteroids (ICS) on eosinophilic inflammation in
asthma is well established, but their effect in a real-life setting has not been extensively …
asthma is well established, but their effect in a real-life setting has not been extensively …
Effects of systemic corticosteroids on blood eosinophil counts in asthma: real-world data
Introduction: Systemic corticosteroids (SCS) are effective anti-inflammatory therapies for
patients with severe or persistent asthma. Use of SCS reduces blood eosinophil counts; the …
patients with severe or persistent asthma. Use of SCS reduces blood eosinophil counts; the …
Inflammation and corticosteroid responsiveness in ex-, current-and never-smoking asthmatics
ED Telenga, HAM Kerstjens, NHT Ten Hacken… - BMC pulmonary …, 2013 - Springer
Background It has been suggested that smoking asthmatics benefit less from corticosteroid
treatment than never-smoking asthmatics. We investigated differences in blood and sputum …
treatment than never-smoking asthmatics. We investigated differences in blood and sputum …
Assessment and evaluation of symptomatic steroid-naive asthmatics without sputum eosinophilia and their response to inhaled corticosteroids
P Godon, LP Boulet, JL Malo, A Cartier… - European Respiratory …, 2002 - Eur Respiratory Soc
Eosinophilic airway inflammation is one of the hallmarks of asthma. Sputum eosinophilia
has been suggested as a predictor of the response to inhaled corticosteroids in asthma. This …
has been suggested as a predictor of the response to inhaled corticosteroids in asthma. This …
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