The role of the vagus nerve in the somnogenic and pyrogenic effects of lipopolysaccharide
(LPS) was studied in rats. Control rats (n= 8) and rats subjected to bilateral subdiaphragmal …

The vagus nerve appears to serve a role in mediating peripheral immunologic influences on
CNS processes. Previous work demonstrates that subdiaphragmatic vagotomy prevents or …

Abstract Study Objective: Systemic tumor necrosis factor-α (TNF-α) is linked to sleep and
sleep altering pathologies in humans. Evidence from animals indicates that systemic and …

Lipopolysaccharide (LPS) is known to produce a number of central and neuroendocrine
effects but the mechanisms involved are still unclear. This study was done to investigate the …

Several recent findings, including the inability of subdiaphragmatic vagotomy to block
lipopolysaccharide (LPS)-induced interleukin-1β (IL-1β) protein in brain, have made it …

The mechanism by which peripheral cytokines signal the central nervous system to elicit
central manifestations of the acute phase response remains unknown. Recent evidence …

It has recently been shown that subdiaphragmatic vagotomy blocks some of the effects of
inflammatory stimuli on brain-controlled functions. Therefore, vagal afferent fibers have been …

The multiple effects of vagotomy on the thermoregulatory response to systemic inflammation
are reviewed (primarily, for the model of intravenous lipopolysaccharide administration in …

It is generally believed that fever is mediated by certain cytokines produced by immune cells
activated by exogenous pyrogens, eg, lipopolysaccharides (LPS), released into the …

Subdiaphragmatic vagotomy decreases the febrile responsiveness to intraperitoneal (ip)
lipopolysaccharide (LPS), but whether this effect is due to interruption of afferent or efferent …