[HTML][HTML] Linkage disequilibrium in humans: models and data
JK Pritchard, M Przeworski - The American Journal of Human Genetics, 2001 - cell.com
In this review, we describe recent empirical and theoretical work on the extent of linkage
disequilibrium (LD) in the human genome, comparing the predictions of simple population …
disequilibrium (LD) in the human genome, comparing the predictions of simple population …
[HTML][HTML] A comparison of linkage disequilibrium patterns and estimated population recombination rates across multiple populations
Large-scale studies of linkage disequilibrium (LD) have shown considerable variation in the
extent and distribution of pairwise LD within and between populations. Taken at face value …
extent and distribution of pairwise LD within and between populations. Taken at face value …
[HTML][HTML] Lower-than-expected linkage disequilibrium between tightly linked markers in humans suggests a role for gene conversion
Understanding the pattern of linkage disequilibrium (LD) in the human genome is important
both for successful implementation of disease-gene mapping approaches and for inferences …
both for successful implementation of disease-gene mapping approaches and for inferences …
Haplotype blocks and linkage disequilibrium in the human genome
JD Wall, JK Pritchard - Nature Reviews Genetics, 2003 - nature.com
There is great interest in the patterns and extent of linkage disequilibrium (LD) in humans
and other species. Characterizing LD is of central importance for gene-mapping studies and …
and other species. Characterizing LD is of central importance for gene-mapping studies and …
[HTML][HTML] Linkage disequilibrium and inference of ancestral recombination in 538 single-nucleotide polymorphism clusters across the human genome
The prospect of using linkage disequilibrium (LD) for fine-scale mapping in humans has
attracted considerable attention, and, during the validation of a set of single-nucleotide …
attracted considerable attention, and, during the validation of a set of single-nucleotide …
Characterization of multilocus linkage disequilibrium
Linkage disequilibrium (LD) in the human genome, often measured as pairwise correlation
between adjacent markers, shows substantial spatial heterogeneity. Congruent with these …
between adjacent markers, shows substantial spatial heterogeneity. Congruent with these …
A scan for linkage disequilibrium across the human genome
Linkage disequilibrium (LD), the tendency for alleles of linked loci to co-occur nonrandomly
on chromosomal haplotypes, is an increasingly useful phenomenon for (1) revealing historic …
on chromosomal haplotypes, is an increasingly useful phenomenon for (1) revealing historic …
[HTML][HTML] Assessing the performance of the haplotype block model of linkage disequilibrium
JD Wall, JK Pritchard - The American Journal of Human Genetics, 2003 - cell.com
Several recent studies have suggested that linkage disequilibrium (LD) in the human
genome has a fundamentally" blocklike" structure. However, thus far there has been little …
genome has a fundamentally" blocklike" structure. However, thus far there has been little …
[HTML][HTML] Demography, recombination hotspot intensity, and the block structure of linkage disequilibrium
MPH Stumpf, DB Goldstein - Current Biology, 2003 - cell.com
Background: Effective gene mapping based on genetic association data will require detailed
knowledge of patterns of linkage disequilibrium (LD) in human populations. It has been …
knowledge of patterns of linkage disequilibrium (LD) in human populations. It has been …
[HTML][HTML] The effect that genotyping errors have on the robustness of common linkage-disequilibrium measures
The rapid development of a dense single-nucleotide–polymorphism marker map has
stimulated numerous studies attempting to characterize the magnitude and distribution of …
stimulated numerous studies attempting to characterize the magnitude and distribution of …