[HTML][HTML] Neuropeptides as targets for the development of anticonvulsant drugs

E Clynen, A Swijsen, M Raijmakers, G Hoogland… - Molecular …, 2014 - Springer
Epilepsy is a common neurological disorder characterized by recurrent seizures. These
seizures are due to abnormal excessive and synchronous neuronal activity in the brain …

Neuropeptides in epilepsy

S Kovac, MC Walker - Neuropeptides, 2013 - Elsevier
Neuropeptides play an important role in modulating seizures and epilepsy. Unlike
neurotransmitters which operate on a millisecond time-scale, neuropeptides have longer …

Nesfatin-1, a unique regulatory neuropeptide of the brain

A Pałasz, M Krzystanek, J Worthington, B Czajkowska… - Neuropeptides, 2012 - Elsevier
Nesfatin-1, a newly discovered NUCB2-derived satiety neuropeptide is expressed in several
neurons of forebrain, hindbrain, brainstem and spinal cord. This novel anorexigenic …

Nesfatin-1 and ghrelin levels in serum and saliva of epileptic patients: hormonal changes can have a major effect on seizure disorders

S Aydin, E Dag, Y Ozkan, F Erman, AF Dagli… - Molecular and cellular …, 2009 - Springer
Nesfatin-1 and ghrelin are the two recently discovered peptide hormones involved in the
control of appetite. Besides its main appetite-control function, ghrelin also has …

Receptors of peptides as therapeutic targets in epilepsy research

A Dobolyi, KA Kékesi, G Juhász… - Current medicinal …, 2014 - ingentaconnect.com
Neuropeptides are signaling molecules participating in the modulation of synaptic
transmission. Neuropeptides are stored in dense core synaptic vesicles, the release of …

Classical neurotransmitters and neuropeptides involved in generalized epilepsy: a focus on antiepileptic drugs

FM Werner, R Coveñas - Current medicinal chemistry, 2011 - ingentaconnect.com
We describe the alterations of classical neurotransmitters and neuropeptides in generalized
epilepsy. A neuronal network in this disease is developed. Gamma aminobutyric acid …

Nesfatin-1: distribution and interaction with a G protein-coupled receptor in the rat brain

GC Brailoiu, SL Dun, E Brailoiu, S Inan, J Yang… - …, 2007 - academic.oup.com
Nesfatin-1 is a recently identified satiety molecule detectable in neurons of the
hypothalamus and nucleus of solitary tract (NTS). Immunohistochemical studies revealed …

What are neuropeptides?

JPH Burbach - Neuropeptides: Methods and protocols, 2011 - Springer
We know neuropeptides now for over 40 years as chemical signals in the brain. The
discovery of neuropeptides is founded on groundbreaking research in physiology …

Ghrelin: an emerging new anticonvulsant neuropeptide

J Portelli, Y Michotte, I Smolders - Epilepsia, 2012 - Wiley Online Library
Neuropeptides appear to be of importance when the central nervous system (CNS) is
challenged, such as during high‐frequency firing and pathologic conditions. Potential …

Neuropeptides: anticonvulsant and convulsant mechanisms in epileptic model systems and in humans.

JG Bajorek, RJ Lee, P Lomax - Advances in neurology, 1986 - europepmc.org
Neuropeptides represent a new class of compounds with important implications for the
understanding of the mechanisms and treatment of epileptic disorders. Several systems of …