[HTML][HTML] Neuropeptides as targets for the development of anticonvulsant drugs
E Clynen, A Swijsen, M Raijmakers, G Hoogland… - Molecular …, 2014 - Springer
Epilepsy is a common neurological disorder characterized by recurrent seizures. These
seizures are due to abnormal excessive and synchronous neuronal activity in the brain …
seizures are due to abnormal excessive and synchronous neuronal activity in the brain …
Neuropeptides in epilepsy
S Kovac, MC Walker - Neuropeptides, 2013 - Elsevier
Neuropeptides play an important role in modulating seizures and epilepsy. Unlike
neurotransmitters which operate on a millisecond time-scale, neuropeptides have longer …
neurotransmitters which operate on a millisecond time-scale, neuropeptides have longer …
Nesfatin-1, a unique regulatory neuropeptide of the brain
A Pałasz, M Krzystanek, J Worthington, B Czajkowska… - Neuropeptides, 2012 - Elsevier
Nesfatin-1, a newly discovered NUCB2-derived satiety neuropeptide is expressed in several
neurons of forebrain, hindbrain, brainstem and spinal cord. This novel anorexigenic …
neurons of forebrain, hindbrain, brainstem and spinal cord. This novel anorexigenic …
Nesfatin-1 and ghrelin levels in serum and saliva of epileptic patients: hormonal changes can have a major effect on seizure disorders
Nesfatin-1 and ghrelin are the two recently discovered peptide hormones involved in the
control of appetite. Besides its main appetite-control function, ghrelin also has …
control of appetite. Besides its main appetite-control function, ghrelin also has …
Receptors of peptides as therapeutic targets in epilepsy research
Neuropeptides are signaling molecules participating in the modulation of synaptic
transmission. Neuropeptides are stored in dense core synaptic vesicles, the release of …
transmission. Neuropeptides are stored in dense core synaptic vesicles, the release of …
Classical neurotransmitters and neuropeptides involved in generalized epilepsy: a focus on antiepileptic drugs
FM Werner, R Coveñas - Current medicinal chemistry, 2011 - ingentaconnect.com
We describe the alterations of classical neurotransmitters and neuropeptides in generalized
epilepsy. A neuronal network in this disease is developed. Gamma aminobutyric acid …
epilepsy. A neuronal network in this disease is developed. Gamma aminobutyric acid …
Nesfatin-1: distribution and interaction with a G protein-coupled receptor in the rat brain
GC Brailoiu, SL Dun, E Brailoiu, S Inan, J Yang… - …, 2007 - academic.oup.com
Nesfatin-1 is a recently identified satiety molecule detectable in neurons of the
hypothalamus and nucleus of solitary tract (NTS). Immunohistochemical studies revealed …
hypothalamus and nucleus of solitary tract (NTS). Immunohistochemical studies revealed …
What are neuropeptides?
JPH Burbach - Neuropeptides: Methods and protocols, 2011 - Springer
We know neuropeptides now for over 40 years as chemical signals in the brain. The
discovery of neuropeptides is founded on groundbreaking research in physiology …
discovery of neuropeptides is founded on groundbreaking research in physiology …
Ghrelin: an emerging new anticonvulsant neuropeptide
J Portelli, Y Michotte, I Smolders - Epilepsia, 2012 - Wiley Online Library
Neuropeptides appear to be of importance when the central nervous system (CNS) is
challenged, such as during high‐frequency firing and pathologic conditions. Potential …
challenged, such as during high‐frequency firing and pathologic conditions. Potential …
Neuropeptides: anticonvulsant and convulsant mechanisms in epileptic model systems and in humans.
JG Bajorek, RJ Lee, P Lomax - Advances in neurology, 1986 - europepmc.org
Neuropeptides represent a new class of compounds with important implications for the
understanding of the mechanisms and treatment of epileptic disorders. Several systems of …
understanding of the mechanisms and treatment of epileptic disorders. Several systems of …