Population Genomic Evidence of Adaptive Response during the Invasion History of Plasmodium falciparum in the Americas
MJM Lefebvre, J Daron, E Legrand… - Molecular Biology …, 2023 - academic.oup.com
Plasmodium falciparum, the most virulent agent of human malaria, spread from Africa to all
continents following the out-of-Africa human migrations. During the transatlantic slave trade …
continents following the out-of-Africa human migrations. During the transatlantic slave trade …
Patterns and dynamics of genetic diversity in Plasmodium falciparum: what past human migrations tell us about malaria
Plasmodium falciparum is the main agent of malaria, one of the major human infectious
diseases affecting millions of people worldwide. The genetic diversity of P. falciparum …
diseases affecting millions of people worldwide. The genetic diversity of P. falciparum …
Whole-Genome Scans Provide Evidence of Adaptive Evolution in Malawian Plasmodium falciparum Isolates
H Ocholla, MD Preston, M Mipando… - The Journal of …, 2014 - academic.oup.com
Background Selection by host immunity and antimalarial drugs has driven extensive
adaptive evolution in Plasmodium falciparum and continues to produce ever-changing …
adaptive evolution in Plasmodium falciparum and continues to produce ever-changing …
Genetic markers of adaptation of Plasmodium falciparum to transmission by American vectors identified in the genomes of parasites from Haiti and South America
MS Tagliamonte, CA Yowell, MA Elbadry, J Boncy… - Msphere, 2020 - Am Soc Microbiol
The malaria parasite, Plasmodium falciparum, was introduced into Hispaniola and other
regions of the Americas through the slave trade spanning the 16th through the 19th …
regions of the Americas through the slave trade spanning the 16th through the 19th …
[HTML][HTML] Resolving drug selection and migration in an inbred South American Plasmodium falciparum population with identity-by-descent analysis
The human malaria parasite Plasmodium falciparum is globally widespread, but its
prevalence varies significantly between and even within countries. Most population genetic …
prevalence varies significantly between and even within countries. Most population genetic …
[HTML][HTML] Plasmodium falciparum accompanied the human expansion out of Africa
Plasmodium falciparum is distributed throughout the tropics and is responsible for an
estimated 230 million cases of malaria every year, with a further 1.4 billion people at risk of …
estimated 230 million cases of malaria every year, with a further 1.4 billion people at risk of …
Evolutionary structure of Plasmodium falciparum major variant surface antigen genes in South America: Implications for epidemic transmission and surveillance
V Rougeron, KE Tiedje, DS Chen, TS Rask… - Ecology and …, 2017 - Wiley Online Library
Strong founder effects resulting from human migration out of Africa have led to geographic
variation in single nucleotide polymorphisms (SNP s) and microsatellites (MS) of the malaria …
variation in single nucleotide polymorphisms (SNP s) and microsatellites (MS) of the malaria …
A Revised Timeline for the Origin of Plasmodium falciparum as a Human Pathogen
JM Baron, JM Higgins, WH Dzik - Journal of molecular evolution, 2011 - Springer
While Plasmodium falciparum is known to have had a strong effect on human evolution, the
time period when P. falciparum first infected ancestors of modern humans has remained …
time period when P. falciparum first infected ancestors of modern humans has remained …
Multiple independent introductions of Plasmodium falciparum in South America
E Yalcindag, E Elguero, C Arnathau… - Proceedings of the …, 2012 - National Acad Sciences
The origin of Plasmodium falciparum in South America is controversial. Some studies
suggest a recent introduction during the European colonizations and the transatlantic slave …
suggest a recent introduction during the European colonizations and the transatlantic slave …
[HTML][HTML] Comparison of genomic signatures of selection on Plasmodium falciparum between different regions of a country with high malaria endemicity
Background Genome wide sequence analyses of malaria parasites from widely separated
areas of the world have identified contrasting population structures and signatures of …
areas of the world have identified contrasting population structures and signatures of …
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