Population Genomic Evidence of Adaptive Response during the Invasion History of Plasmodium falciparum in the Americas

MJM Lefebvre, J Daron, E Legrand… - Molecular Biology …, 2023 - academic.oup.com
Plasmodium falciparum, the most virulent agent of human malaria, spread from Africa to all
continents following the out-of-Africa human migrations. During the transatlantic slave trade …

Patterns and dynamics of genetic diversity in Plasmodium falciparum: what past human migrations tell us about malaria

T Mita, T Jombart - Parasitology international, 2015 - Elsevier
Plasmodium falciparum is the main agent of malaria, one of the major human infectious
diseases affecting millions of people worldwide. The genetic diversity of P. falciparum …

Whole-Genome Scans Provide Evidence of Adaptive Evolution in Malawian Plasmodium falciparum Isolates

H Ocholla, MD Preston, M Mipando… - The Journal of …, 2014 - academic.oup.com
Background Selection by host immunity and antimalarial drugs has driven extensive
adaptive evolution in Plasmodium falciparum and continues to produce ever-changing …

Genetic markers of adaptation of Plasmodium falciparum to transmission by American vectors identified in the genomes of parasites from Haiti and South America

MS Tagliamonte, CA Yowell, MA Elbadry, J Boncy… - Msphere, 2020 - Am Soc Microbiol
The malaria parasite, Plasmodium falciparum, was introduced into Hispaniola and other
regions of the Americas through the slave trade spanning the 16th through the 19th …

[HTML][HTML] Resolving drug selection and migration in an inbred South American Plasmodium falciparum population with identity-by-descent analysis

M Carrasquilla, AM Early, AR Taylor… - PLoS …, 2022 - journals.plos.org
The human malaria parasite Plasmodium falciparum is globally widespread, but its
prevalence varies significantly between and even within countries. Most population genetic …

[HTML][HTML] Plasmodium falciparum accompanied the human expansion out of Africa

K Tanabe, T Mita, T Jombart, A Eriksson, S Horibe… - Current Biology, 2010 - cell.com
Plasmodium falciparum is distributed throughout the tropics and is responsible for an
estimated 230 million cases of malaria every year, with a further 1.4 billion people at risk of …

Evolutionary structure of Plasmodium falciparum major variant surface antigen genes in South America: Implications for epidemic transmission and surveillance

V Rougeron, KE Tiedje, DS Chen, TS Rask… - Ecology and …, 2017 - Wiley Online Library
Strong founder effects resulting from human migration out of Africa have led to geographic
variation in single nucleotide polymorphisms (SNP s) and microsatellites (MS) of the malaria …

A Revised Timeline for the Origin of Plasmodium falciparum as a Human Pathogen

JM Baron, JM Higgins, WH Dzik - Journal of molecular evolution, 2011 - Springer
While Plasmodium falciparum is known to have had a strong effect on human evolution, the
time period when P. falciparum first infected ancestors of modern humans has remained …

Multiple independent introductions of Plasmodium falciparum in South America

E Yalcindag, E Elguero, C Arnathau… - Proceedings of the …, 2012 - National Acad Sciences
The origin of Plasmodium falciparum in South America is controversial. Some studies
suggest a recent introduction during the European colonizations and the transatlantic slave …

[HTML][HTML] Comparison of genomic signatures of selection on Plasmodium falciparum between different regions of a country with high malaria endemicity

CW Duffy, SA Assefa, J Abugri, N Amoako… - BMC genomics, 2015 - Springer
Background Genome wide sequence analyses of malaria parasites from widely separated
areas of the world have identified contrasting population structures and signatures of …