Iron metabolism in infections: Focus on COVID-19

D Girelli, G Marchi, F Busti, A Vianello - Seminars in hematology, 2021 - Elsevier
Iron is a micronutrient essential for a wide range of metabolic processes in virtually all living
organisms. During infections, a battle for iron takes place between the human host and the …

Iron: Innocent bystander or vicious culprit in COVID-19 pathogenesis?

M Edeas, J Saleh, C Peyssonnaux - International Journal of Infectious …, 2020 - Elsevier
Abstract The coronavirus 2 (SARS-CoV-2) pandemic is viciously spreading through the
continents with rapidly increasing mortality rates. Current management of COVID-19 is …

Iron and iron-related proteins in COVID-19

E Suriawinata, KJ Mehta - Clinical and experimental medicine, 2023 - Springer
COVID-19 can cause detrimental effects on health. Vaccines have helped in reducing
disease severity and transmission but their long-term effects on health and effectiveness …

Persisting alterations of iron homeostasis in COVID-19 are associated with non-resolving lung pathologies and poor patients' performance: a prospective …

T Sonnweber, A Boehm, S Sahanic, A Pizzini… - Respiratory …, 2020 - Springer
Background Severe coronavirus disease 2019 (COVID-19) is frequently associated with
hyperinflammation and hyperferritinemia. The latter is related to increased mortality in …

Iron dysregulation and inflammatory stress erythropoiesis associates with long-term outcome of COVID-19

AL Hanson, MP Mulè, H Ruffieux, F Mescia… - Nature …, 2024 - nature.com
Persistent symptoms following SARS-CoV-2 infection are increasingly reported, although
the drivers of post-acute sequelae (PASC) of COVID-19 are unclear. Here we assessed 214 …

Increased serum catalytic iron may mediate tissue injury and death in patients with COVID-19

V Chakurkar, M Rajapurkar, S Lele, B Mukhopadhyay… - Scientific reports, 2021 - nature.com
The pathophysiology and the factors determining disease severity in COVID-19 are not yet
clear, with current data indicating a possible role of altered iron metabolism. Previous …

COVID-19 as part of the hyperferritinemic syndromes: the role of iron depletion therapy

C Perricone, E Bartoloni, R Bursi, G Cafaro… - Immunologic …, 2020 - Springer
SARS-CoV-2 infection is characterized by a protean clinical picture that can range from
asymptomatic patients to life-threatening conditions. Severe COVID-19 patients often display …

Prevalence and predictive value of anemia and dysregulated iron homeostasis in patients with COVID-19 infection

R Bellmann-Weiler, L Lanser, R Barket… - Journal of clinical …, 2020 - mdpi.com
Infections with SARS-CoV-2 can result in severe clinical manifestations. As such patients
present with systemic inflammation, we studied the prevalence and predictive value of …

SARS-CoV-2 infection dysregulates host iron (Fe)-redox homeostasis (Fe-RH): role of Fe-redox regulators, ferroptosis inhibitors, anticoagulants, and iron-chelators in …

SAG Naidu, RA Clemens, AS Naidu - Journal of dietary …, 2023 - Taylor & Francis
Severe imbalance in iron metabolism among SARS-CoV-2 infected patients is prominent in
every symptomatic (mild, moderate to severe) clinical phase of COVID-19. Phase-I–Hypoxia …

Association between iron status and the risk of adverse outcomes in COVID-19

Y Lv, L Chen, X Liang, X Liu, M Gao, Q Wang, Q Wei… - Clinical Nutrition, 2021 - Elsevier
Background & aims Iron is an essential trace element to almost all organism, and the
delicate balance between host defend system and viral proliferation plays an important role …