Kinetics and dose dependency of intranasal oxytocin effects on amygdala reactivity

FB Spengler, J Schultz, D Scheele, M Essel, W Maier… - Biological …, 2017 - Elsevier
Background Current neuroimaging perspectives on a variety of mental disorders emphasize
dysfunction of the amygdala. The neuropeptide oxytocin (OXT), a key mediator in the …

Oxytocin-augmented psychotherapy: beware of context

R Hurlemann - Neuropsychopharmacology, 2017 - ncbi.nlm.nih.gov
The hypothalamic peptide oxytocin modulates a wide range of social and cognitive functions
in humans and nonhuman primates. As a result, much effort is currently being devoted to …

A randomized trial shows dose-frequency and genotype may determine the therapeutic efficacy of intranasal oxytocin

J Kou, Y Zhang, F Zhou, C Sindermann… - Psychological …, 2022 - cambridge.org
BackgroundThe neuropeptide oxytocin is proposed as a promising therapy for social
dysfunction by modulating amygdala-mediated social-emotional behavior. Although clinical …

[HTML][HTML] Low dose intranasal oxytocin delivered with Breath Powered device dampens amygdala response to emotional stimuli: A peripheral effect-controlled within …

DS Quintana, LT Westlye, D Alnæs, ØG Rustan… - …, 2016 - Elsevier
It is unclear if and how exogenous oxytocin (OT) reaches the brain to improve social
behavior and cognition and what is the optimal dose for OT response. To better understand …

Oxytocin differentially alters resting state functional connectivity between amygdala subregions and emotional control networks: Inverse correlation with depressive …

M Eckstein, S Markett, KM Kendrick, B Ditzen, F Liu… - Neuroimage, 2017 - Elsevier
The hypothalamic neuropeptide oxytocin (OT) has received increasing attention for its role in
modulating social-emotional processes across species. Previous studies on using intranasal …

Kinetics of oxytocin effects on amygdala and striatal reactivity vary between women and men

J Lieberz, D Scheele, FB Spengler… - …, 2020 - nature.com
Accumulating evidence suggests that intranasal oxytocin (OXT; 24 IU) reduces amygdala
responses to fear-related stimuli in men, while exerting inverse effects in women. However …

Oxytocin and brain activity in humans: a systematic review and coordinate-based meta-analysis of functional MRI studies

SA Grace, SL Rossell, M Heinrichs… - …, 2018 - Elsevier
Oxytocin (OXT) is a neuropeptide which has a critical role in human social behaviour and
cognition. Research investigating the role of OXT on functional brain changes in humans …

Oxytocin enhances resting-state connectivity between amygdala and medial frontal cortex

CS Sripada, KL Phan, I Labuschagne… - International Journal …, 2013 - academic.oup.com
The neuropeptide oxytocin (OXT) plays an important role in complex socio-affective
behaviours such as affiliation, attachment, stress and anxiety. Previous studies have focused …

Neural substrates underlying the effects of oxytocin: a quantitative meta-analysis of pharmaco-imaging studies

D Wang, X Yan, M Li, Y Ma - Social Cognitive and Affective …, 2017 - academic.oup.com
The hypothalamic peptide oxytocin (OT) is crucial in social adaptation and used to treat
emotional and social deficits. Here, we conducted a systematic, quantitative meta-analysis of …

Oxytocin, brain physiology, and functional connectivity: a review of intranasal oxytocin fMRI studies

RAI Bethlehem, J Van Honk, B Auyeung… - …, 2013 - Elsevier
In recent years the neuropeptide oxytocin (OT) has become one of the most studied peptides
of the human neuroendocrine system. Research has shown widespread behavioural effects …