Hemophagocytic lymphohistiocytosis (HLH) is a rare disorder with familial and acquired
forms. The familial form is associated with mutations in the perforin gene and both forms are …

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome in which an
uncontrolled and ineffective immune response, triggered in most cases by infectious agents …

Hemophagocytic lymphohistiocytosis (HLH) is a rare life‐threatening disease in which the
immune system becomes overactive due to its inability to effectively respond to infections …

Familial hemophagocytic lymphohistiocytosis (FHL) is a rare, rapidly fatal, autosomal
recessive immune disorder characterized by uncontrolled activation of T cells and …

Mutations in the perforin gene have been described in some patients with hemophagocytic
lymphohistiocytosis (HLH), but the role of perforin defects in the pathogenesis of HLH …

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome in which an
exaggerated but ineffective immune response leads to severe hyperinflammation. Key …

Familial hemophagocytic lymphohistiocytosis (FHL) is an autosomal recessive disease of
early childhood characterized by nonmalignant accumulation and multivisceral infiltration of …

Mutations of the perforin (PRF1) and MUNC13-4 genes distinguish 2 forms of familial
hemophagocytic lymphohistiocytosis (FHL2 and FHL3, respectively), but the clinical and …

Context.—Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening disorder of
immune regulation that can eventually result in end-organ damage and death. HLH is …

Hemophagocytic lymphohistiocytosis (HLH) is not an independent disease but rather a life-
threatening clinical syndrome that occurs in many underlying conditions and in all age …