Background The interaction of coagulation factors has been shown to go beyond their
traditional roles in hemostasis and to affect the development of inflammatory diseases. Key …

Fibrinogen and factor XIII are two essential proteins that are involved directly in fibrin gel
formation as the final step of a sequence of reactions triggered by a procoagulant stimulus …

Combinations of proinflammatory and procoagulant reactions are the unifying principle for a
variety of disorders affecting the cardiovascular system. The factor XII–driven contact system …

The interaction of coagulation factors with the perivascular environment affects the
development of disease in ways that extend beyond their traditional roles in the acute …

Highlights•FXII is selectively important for thrombosis and has no role in hemostasis.•Platelet-
released polyphosphates activate FXII in thrombosis.•FXIIa-inhibiting antibody 3F7 blocks …

Plasma protein factor XII (FXII) activates the procoagulant and proinflammatory contact
system that drives both the kallikrein–kinin system and the intrinsic pathway of coagulation …

Factor XII (FXII) is a protease that is mainly produced in the liver and circulates in plasma as
a single chain zymogen. Following contact with negatively charged surfaces, FXII is …

Coagulation factor XII (FXII, Hageman factor) is a plasma protease that in its active form
(FXIIa) initiates the procoagulant and proinflammatory contact system. This name arises from …

Physiologic hemostasis upon injury involves many plasma proteins in a well-regulated
cascade of proteolytic reactions to form a clot. Deficiency of blood coagulation Factors VIII …

FXIII (Factor XIII) is a Ca2+-dependent enzyme which forms covalent ϵ-(γ-glutamyl) lysine
cross-links between the γ-carboxy-amine group of a glutamine residue and the ϵ-amino …