Identification of WRKY transcription factors involved in regulating the biosynthesis of the anti-cancer drug camptothecin in Ophiorrhiza pumila
Camptothecin is a chemotherapeutic drug widely used to treat various cancers. Ophiorrhiza
pumila is an ideal plant model for the study of camptothecin production, with various …
pumila is an ideal plant model for the study of camptothecin production, with various …
The transcription factor OpWRKY2 positively regulates the biosynthesis of the anticancer drug camptothecin in Ophiorrhiza pumila
X Hao, C Xie, Q Ruan, X Zhang, C Wu… - Horticulture …, 2021 - academic.oup.com
The limited bioavailability of plant-derived natural products with anticancer activity poses
major challenges to the pharmaceutical industry. An example of this is camptothecin, a …
major challenges to the pharmaceutical industry. An example of this is camptothecin, a …
WRKY transcription factor OpWRKY1 acts as a negative regulator of camptothecin biosynthesis in Ophiorrhiza pumila hairy roots
M Xu, C Wu, L Zhao, Y Wang, C Wang, W Zhou… - Plant Cell, Tissue and …, 2020 - Springer
Camptothecin (CPT) has unique anti-tumor activities, and its analogs such as irinotecan and
topotecan are clinically used as anti-cancer drugs. Recently, CPT biosynthesis pathway is …
topotecan are clinically used as anti-cancer drugs. Recently, CPT biosynthesis pathway is …
Transcription Factor OpWRKY3 Is Involved in the Development and Biosynthesis of Camptothecin and Its Precursors in Ophiorrhiza pumila Hairy Roots
C Wang, C Wu, Y Wang, C Xie, M Shi, S Nile… - International journal of …, 2019 - mdpi.com
The plant Ophiorrhiza pumila produces camptothecin (CPT), a kind of terpene indole
alkaloid (TIAs) that has been widely used in treatment of cancer. Tryptophan-arginine-lysine …
alkaloid (TIAs) that has been widely used in treatment of cancer. Tryptophan-arginine-lysine …
Comprehensive analysis of OpHD-ZIP transcription factors related to the regulation of camptothecin biosynthesis in Ophiorrhiza pumila
J Wang, Y Li, Y Yang, C Xiao, Q Ruan, P Li… - International Journal of …, 2023 - Elsevier
Ophiorrhiza pumila, as a folk herb belonging to the Rubiaceae family, has become a
potential source of camptothecin (CPT), which is a monoterpenoid indole alkaloid with good …
potential source of camptothecin (CPT), which is a monoterpenoid indole alkaloid with good …
Tyrosine phosphorylation and protein degradation control the transcriptional activity of WRKY involved in benzylisoquinoline alkaloid biosynthesis
Y Yamada, F Sato - Scientific Reports, 2016 - nature.com
Benzylisoquinoline alkaloids (BIQ) are among the most structurally diverse and
pharmaceutically valuable secondary metabolites. A plant-specific WRKY-type transcription …
pharmaceutically valuable secondary metabolites. A plant-specific WRKY-type transcription …
An MYB transcription factor regulating specialized metabolisms in Ophiorrhiza pumila
ER Rohani, M Chiba, M Kawaharada, T Asano… - Plant …, 2016 - jstage.jst.go.jp
Camptothecin is a plant-derived alkaloid and important precursor of clinically used anti-
tumor drugs, but little is known about regulatory mechanism of camptothecin production in …
tumor drugs, but little is known about regulatory mechanism of camptothecin production in …
Two polyamines-responsive WRKY transcription factors from Anoectochilus roxburghii play opposite functions on flower development
B Xing, S Wan, L Su, MW Riaz, L Li, Y Ju, W Zhang… - Plant Science, 2023 - Elsevier
Anoectochilus roxburghii is a rare and precious plant with medicinal and healthcare
functions. Embryo abortion caused the lack of resources. Polyamine promoted its flowering …
functions. Embryo abortion caused the lack of resources. Polyamine promoted its flowering …
Genome-Wide Profiling of WRKY Genes Involved in Benzylisoquinoline Alkaloid Biosynthesis in California Poppy (Eschscholzia californica)
Transcription factors of the WRKY family play pivotal roles in plant defense responses,
including the biosynthesis of specialized metabolites. Based on the previous findings of …
including the biosynthesis of specialized metabolites. Based on the previous findings of …
The jasmonate-responsive transcription factor CbWRKY24 regulates terpenoid biosynthetic genes to promote saponin biosynthesis in Conyza blinii H. Lév.
WJ Sun, JY Zhan, TR Zheng, R Sun, T Wang… - Journal of genetics, 2018 - Springer
Conyza blinii H. Lév., the most effective component is saponin, is a biennial medicinal
material that needs to be overwintered. WRKY transcription factors family is a large protein …
material that needs to be overwintered. WRKY transcription factors family is a large protein …
相关搜索
- ophiorrhiza pumila camptothecin biosynthesis
- transcription factors camptothecin biosynthesis
- ophiorrhiza pumila transcription factors
- negative regulator camptothecin biosynthesis
- ophiorrhiza pumila negative regulator
- comprehensive analysis camptothecin biosynthesis
- ophiorrhiza pumila comprehensive analysis
- comprehensive analysis transcription factors
- ophiorrhiza pumila drug camptothecin
- transcription factor drug camptothecin
- transcription factor saponin biosynthesis