Camptothecin is a chemotherapeutic drug widely used to treat various cancers. Ophiorrhiza
pumila is an ideal plant model for the study of camptothecin production, with various …

The limited bioavailability of plant-derived natural products with anticancer activity poses
major challenges to the pharmaceutical industry. An example of this is camptothecin, a …

Camptothecin (CPT) has unique anti-tumor activities, and its analogs such as irinotecan and
topotecan are clinically used as anti-cancer drugs. Recently, CPT biosynthesis pathway is …

The plant Ophiorrhiza pumila produces camptothecin (CPT), a kind of terpene indole
alkaloid (TIAs) that has been widely used in treatment of cancer. Tryptophan-arginine-lysine …

Ophiorrhiza pumila, as a folk herb belonging to the Rubiaceae family, has become a
potential source of camptothecin (CPT), which is a monoterpenoid indole alkaloid with good …

Benzylisoquinoline alkaloids (BIQ) are among the most structurally diverse and
pharmaceutically valuable secondary metabolites. A plant-specific WRKY-type transcription …

Camptothecin is a plant-derived alkaloid and important precursor of clinically used anti-
tumor drugs, but little is known about regulatory mechanism of camptothecin production in …

Anoectochilus roxburghii is a rare and precious plant with medicinal and healthcare
functions. Embryo abortion caused the lack of resources. Polyamine promoted its flowering …

Transcription factors of the WRKY family play pivotal roles in plant defense responses,
including the biosynthesis of specialized metabolites. Based on the previous findings of …

Conyza blinii H. Lév., the most effective component is saponin, is a biennial medicinal
material that needs to be overwintered. WRKY transcription factors family is a large protein …