Temsirolimus is a first-generation mTOR inhibitor commonly used in the clinical treatment of
cancers that is associated with lung injury. However, the mechanism underlying this adverse …

Polymorphonuclear neutrophil (PMN) extravasation requires selectin-mediated tethering,
intercellular adhesion molecule-1 (ICAM-1)–dependent firm adhesion, and …

Platelet endothelial cell adhesion molecule-1 (PECAM-1)(CD31) is an adhesion molecule
believed to mediate transendothelial migration of neutrophils and other leukocytes after …

Transendothelial migration (TEM) of neutrophils under blood flow is critical in the
inflammatory cascade. However, the role of endothelial plasticity in this process is not fully …

Platelet endothelial cell adhesion molecule‑1 (PECAM‑1) is expressed on the vascular
endothelium and has been implicated in the late progression of metastatic tumors. The …

Background During inflammation, adhesion molecules regulate recruitment of leukocytes to
inflamed tissues. It is reported that vascular cell adhesion molecule-1 (VCAM-1) activates …

Background: One of the important pathogenesis of acute respiratory distress syndrome
(ARDS) is the dysfunction of pulmonary microvascular endothelial barrier induced by a …

Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31), a tyrosine phosphoprotein
highly expressed on endothelial cells and leukocytes, is an important component in the …

Polymorphonuclear neutrophils (PMN) adhere to the vascular endothelium under hypoxic
conditions, causing microvascular injury. The molecular mechanism of hypoxia-induced …

The migration of neutrophils from the blood circulation to sites of infection or injury is a key
immune response and requires the breaching of endothelial cells (ECs) that line the inner …