Importance Hereditary cancer risk is informed by the presence of a germline gene variant
more so than by family history of cancer. Objective To assess gastric cancer risk among …

Pathogenic CDH1 germline mutations are associated with lobular breast cancer in the so-
called hereditary lobular breast cancer (HLBC) syndrome, without apparent correlation with …

Introduction Germline CDH1 mutations, classically associated with hereditary diffuse gastric
cancer (HDGC), also imply an increased lifetime risk of developing lobular breast cancer …

Background & Aims Pathogenic germline variants in CDH1 are associated with risk for
diffuse gastric cancer (DGC) and lobular breast cancer. The reported high incidence of DGC …

Introduction CDH1 predisposes primarily to diffuse gastric cancer (DGC). Multiple DGC
cases in a family, DGC at a young age in an individual or the combination of DGC …

Recent studies have reported germline CDH1 mutations in cases of lobular breast cancer
(LBC) not associated with the classical hereditary diffuse gastric cancer syndrome. A …

Background Gastric cancer is the fifth most prevalent and the third most lethal cancer
worldwide, causing approximately 720,000 deaths annually. Although most cases of gastric …

Background Truncating pathogenic or likely pathogenic variants of CDH1 cause hereditary
diffuse gastric cancer (HDGC), a tumour risk syndrome that predisposes carrier individuals …

Hereditary diffuse gastric cancer (HDGC) is an autosomal dominant inherited cancer
syndrome that has been associated with a mutation of the CDH1, and rarely the CTNNA1 …

Importance CDH1variants are increasingly identified on commercially available multigene
panel tests, calling for data to inform counseling of individuals without a family history of …