There are different animal models to evaluate pain among them the formalin hind paw assay
which is widely used since some of its events appear to be similar to the clinical pain of …

Different NSAIDs are used as antinociceptive in various analgesic assays, among which
should be mentioned: ibuprofen, ketorolac, ketoprofen, meloxicam, paracetamol and others …

The antinociceptive activity of several nonsteroidal anti‐inflammatory drugs (NSAIDs) that
were administered either intraperitoneally or intrathecally was assessed in mice by two …

Studies with inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 inhibitor were
conducted to assess their synergistic antinociceptive effect and possible therapeutic …

Background In the past decade it has been shown that tolerance develops to the
antinociceptive effect of repeated systemic administration of commonly used non-steroidal …

Co-administration of the nitric oxide synthase inhibitor, 7-nitro indazole (1 mg/kg i.[.), with the
cyclooxygenase inhibitor, flurbiprofen (5–75 mg/kg ip), resulted in significantly enhanced …

The formalin test in mice is a valid and reliable model of nociception and is sensitive for
various classes of analgesic drugs. The noxious stimulus is an injection of dilute formalin …

Combinations of NSAIDs and opioids are currently employed for the treatment of moderate-
to-severe pain in order to obtain an increased analgesic esponse, allowing the use of low …

The common mechanism of action of non‐steroidal anti‐inflammatory drugs (NSAIDs) is the
inhibition of the enzyme cyclo‐oxygenase (COX), however, this inhibition is not enough to …

The involvement of the nitric oxide–cyclic GMP pathway in the peripheral antinociception
induced by the COX-2 preferential inhibitor nimesulide was assessed by using the formalin …