Until recently, the polymyxin antibiotics were used sparingly due to dose limiting toxicities.
However, the lack of therapeutic alternatives for infections caused by highly resistant Gram …

Polymyxins are well-established antibiotics that have recently regained significant interest
as a consequence of the increasing incidence of infections due to multidrug-resistant Gram …

The polymyxins, colistin (also known as polymyxin E) and polymyxin B, have a unique and
interesting history. Originally introduced in the 1950s for the treatment of infections due to …

Polymyxins, including polymyxin B and polymyxin E (colistin), are now increasingly being
used worldwide to treat patients with multidrug-resistant (MDR) Gram-negative bacterial …

Abstract Purpose of Review The polymyxins are one of the last line antimicrobial classes to
retain activity against multidrug-resistant Gram-negative bacilli. However, with the increased …

Recently, plasmid-mediated and, therefore, transferable bacterial polymyxin resistance was
discovered in strains from both humans and animals. Such a trait may widely spread …

Emerging multidrug-resistant (MDR) nosocomial pathogens are a great threat. Polymyxins,
an old class of cationic polypeptide antibiotic, are considered as last-resort drugs in treating …

Confronting the storm of carbapenemase-producing Gram-negative pathogens and thus
facing the threat of untreatable infections, the medical community revived colistin. Not long …

Colistin, also referred to as polymyxin E, is an effective antibiotic against most multidrug-
resistant Gram-negative bacteria and is currently used as a last-line drug for treating severe …

Antibiotic resistance is an ever-increasing global problem. Major commercial antibiotics
often fail to fight common bacteria, and some pathogens have become multi-resistant …