Combating tigecycline resistant Acinetobacter baumannii: A leap forward towards multi-epitope based vaccine discovery

S Ahmad, KE Ranaghan, SS Azam - European Journal of Pharmaceutical …, 2019 - Elsevier
Global emergence of Tigecycline resistant Acinetobacter baumannii (TRAB) is on the
horizon and poses a very serious threat to human health. There is a pressing demand for …

Promising Acinetobacter baumannii Vaccine Candidates and Drug Targets in Recent Years

YC Tan, C Lahiri - Frontiers in Immunology, 2022 - frontiersin.org
In parallel to the uncontrolled use of antibiotics, the emergence of multidrug-resistant
bacteria, like Acinetobacter baumannii, has posed a severe threat. A. baumannii …

Identification and construction of a multi-epitopes vaccine design against Klebsiella aerogenes: molecular modeling study

SI Alzarea - Scientific Reports, 2022 - nature.com
A rapid rise in antibiotic resistance by bacterial pathogens is due to these pathogens
adaptation to the changing environmental conditions. Antibiotic resistance infections can be …

Identification of Novel Vaccine Candidates against Multidrug-Resistant Acinetobacter baumannii

DG Moriel, SA Beatson, DJ Wurpel, J Lipman… - PloS one, 2013 - journals.plos.org
Acinetobacter baumannii is an emerging opportunistic bacterium associated with
nosocomial infections in intensive care units. The alarming increase in infections caused by …

In silico screening of antigenic B-cell derived T-cell epitopes and designing of a multi-epitope peptide vaccine for Acinetobacter nosocomialis

R Sajjad, S Ahmad, SS Azam - Journal of Molecular Graphics and …, 2020 - Elsevier
Globally, antibiotic-resistant and tolerated bacterial isolates of Acinetobacter species are
imposing high financial cost on health care systems and as such, molecular targets with …

Proteomics-based vaccine targets annotation and design of multi-epitope vaccine against antibiotic-resistant Streptococcus gallolyticus

P Chao, X Zhang, L Zhang, A Yang, Y Wang… - Scientific Reports, 2024 - nature.com
Streptococcus gallolyticus is a non-motile, gram-positive bacterium that causes infective
endocarditis. S. gallolyticus has developed resistance to existing antibiotics, and no vaccine …

Antibiotic Resistance Determinant-Focused Acinetobacter baumannii Vaccine Designed Using Reverse Vaccinology

Z Ni, Y Chen, E Ong, Y He - International journal of molecular sciences, 2017 - mdpi.com
As one of the most influential and troublesome human pathogens, Acinetobacter baumannii
(A. baumannii) has emerged with many multidrug-resistant strains. After collecting 33 …

Vaccinomics to design a novel single chimeric subunit vaccine for broad-spectrum immunological applications targeting nosocomial Enterobacteriaceae pathogens

S Ismail, S Ahmad, SS Azam - European Journal of Pharmaceutical …, 2020 - Elsevier
Healthcare associated infections (HAIs) are major cause of elevated mortality, morbidity, and
high healthcare costs. Development of a vaccine targeting these pathogens could benefit in …

Vaccinomics to Design a Multi-Epitopes Vaccine for Acinetobacter baumannii

M Ud-Din, A Albutti, A Ullah, S Ismail, S Ahmad… - International Journal of …, 2022 - mdpi.com
Antibiotic resistance (AR) is the result of microbes' natural evolution to withstand the action
of antibiotics used against them. AR is rising to a high level across the globe, and novel …

Subtractive proteomics to identify novel drug targets and reverse vaccinology for the development of chimeric vaccine against Acinetobacter baumannii

V Solanki, V Tiwari - Scientific reports, 2018 - nature.com
The emergence of drug-resistant Acinetobacter baumannii is the global health problem
associated with high mortality and morbidity. Therefore it is high time to find a suitable …