Morphine, a powerful analgesic, and norepinephrine, the principal neurotransmitter of
sympathetic nerves, exert major inhibitory effects on both peripheral and brain neurons by …

G-protein-coupled receptors (GPCRs) are key signaling proteins that mostly function as
monomers, but for several receptors constitutive dimer formation has been described and in …

Abstract µ-Opioid receptors (µORs) are G-protein-coupled receptors that are activated by a
structurally diverse spectrum of natural and synthetic agonists including endogenous …

The μ-opioid receptor (μOR) is a G-protein-coupled receptor (GPCR) and the target of most
clinically and recreationally used opioids. The induced positive effects of analgesia and …

Opioids represent widely prescribed and abused medications, although their signal
transduction mechanisms are not well understood. Here we present the 1.8 Å high …

G protein-coupled receptors play a pivotal role in many physiological signaling pathways.
Mounting evidence suggests that G protein-coupled receptors, including opioid receptors …

The G protein-coupled μ-opioid receptor (μOR) mediates the physiological effects of
endogenous opioid peptides as well as the structurally distinct opioid alkaloids morphine …

Adrenergic and opioid receptors belong to the rhodopsin family of G-protein coupled
receptors, couple to analogous signal transduction pathways, and affect the nociceptive …

Opium is one of the world's oldest drugs, and its derivatives morphine and codeine are
among the most used clinical drugs to relieve severe pain. These prototypical opioids …

Differential regulation of the μ-opioid receptor (MOR), a G protein (heterotrimeric guanine
nucleotide–binding protein)–coupled receptor, contributes to the clinically limiting effects of …