WNT signaling in cardiac and vascular disease

S Foulquier, EP Daskalopoulos, G Lluri… - Pharmacological …, 2018 - ASPET
WNT signaling is an elaborate and complex collection of signal transduction pathways
mediated by multiple signaling molecules. WNT signaling is critically important for …

Wnt signaling in cardiovascular disease: opportunities and challenges

A Gay, DA Towler - Current opinion in lipidology, 2017 - journals.lww.com
Components of the Wnt signaling cascade represent novel targets for pharmacological
intervention in cardiometabolic disease. Conversely, strategies targeting the Wnt signaling …

Wnt signaling in cardiovascular physiology

K Marinou, C Christodoulides, C Antoniades… - Trends in Endocrinology …, 2012 - cell.com
Wnt signaling pathways play a key role in cardiac development, angiogenesis, and cardiac
hypertrophy; emerging evidence suggests that they are also involved in the pathophysiology …

An updated overview on Wnt signaling pathways: a prelude for more

TP Rao, M Kühl - Circulation research, 2010 - Am Heart Assoc
Growth factor signaling is required for cellular differentiation, tissue morphogenesis, and
tissue homeostasis. Misregulation of intracellular signal transduction can lead to …

Wnt signaling: an essential regulator of cardiovascular differentiation, morphogenesis and progenitor self-renewal

ED Cohen, Y Tian, EE Morrisey - 2008 - journals.biologists.com
Emerging evidence indicates that Wnt signaling regulates crucial aspects of cardiovascular
biology (including cardiac morphogenesis, and the self-renewal and differentiation of …

The Wnt/frizzled pathway in cardiovascular development and disease: friend or foe?

VAM van de Schans, JFM Smits… - European journal of …, 2008 - Elsevier
Proteins from the Wnt family have been implicated in cell–cell communication in a wide
variety of developmental and physiological processes. Wnt signaling is required for different …

Non-canonical WNT signalling in cardiovascular disease: mechanisms and therapeutic implications

I Akoumianakis, M Polkinghorne… - Nature Reviews …, 2022 - nature.com
WNT signalling comprises a diverse spectrum of receptor-mediated pathways activated by a
large family of WNT ligands and influencing fundamental biological processes. WNT …

Wnt signalling in smooth muscle cells and its role in cardiovascular disorders

C Mill, SJ George - Cardiovascular research, 2012 - academic.oup.com
Vascular smooth muscle cells (SMCs) are the major cell type within blood vessels. SMCs
exhibit low rates of proliferation, migration, and apoptosis in normal blood vessels. However …

WNT signaling in adult cardiac hypertrophy and remodeling: lessons learned from cardiac development

MW Bergmann - Circulation research, 2010 - Am Heart Assoc
On pathological stress, the heart reactivates several signaling pathways that traditionally
were thought to be operational only in the developing heart. One of these pathways is the …

Wnt signaling is critical for maladaptive cardiac hypertrophy and accelerates myocardial remodeling

P Malekar, M Hagenmueller, A Anyanwu, S Buss… - …, 2010 - Am Heart Assoc
The evolutionary conserved Wnt signaling pathway regulates cardiogenesis. However,
members of the Wnt pathway are also expressed in the adult heart. Although Wnt-signaling …