Decreased levels of hydrogen sulfide in the hypothalamic paraventricular nucleus contribute to sympathetic hyperactivity induced by cerebral infarction

J Sun, Y Miao, P Wang, Q Guo, D Tian, H Xue… - Hypertension …, 2024 - nature.com
Paroxysmal sympathetic hyperactivity (PSH) is a common clinical feature secondary to
ischemic stroke (IS), but its mechanism is poorly understood. We aimed to investigate the …

Hypothalamic paraventricular nucleus hydrogen sulfide exerts antihypertensive effects in spontaneously hypertensive rats via the Nrf2 pathway

WJ Xia, KL Liu, XM Wang, Y Yang… - American journal of …, 2023 - academic.oup.com
Abstract Background Hydrogen sulfide (H2S) is widely distributed throughout the nervous
system with various antioxidant and anti-inflammatory properties. Hypertension involves an …

Multiple hemodynamic effects of endogenous hydrogen sulfide on central nervous system in rats

Y Ren, S Wu, X Wang, YU Fang, Z Jing… - Chinese Medical …, 2011 - journals.lww.com
Background Endogenous hydrogen sulfide is a new neuromodulator which takes part in the
regulation of central nervous system physiology and diseases. Whether endogenous …

Hydrogen sulfide in paraventricular nucleus attenuates blood pressure by regulating oxidative stress and inflammatory cytokines in high salt-induced hypertension

YF Liang, DD Zhang, XJ Yu, HL Gao, KL Liu, J Qi… - Toxicology Letters, 2017 - Elsevier
Hydrogen sulfide (H 2 S) is an important gaseous signaling molecule in neuro-modulation,
anti-inflammatory, anti-oxidant and anti-hypertensive effects. The paraventricular nucleus …

The baroreflex afferent pathway plays a critical role in H2S-mediated autonomic control of blood pressure regulation under physiological and hypertensive conditions

Y Li, Y Feng, L Liu, X Li, X Li, X Sun, K Li… - Acta Pharmacologica …, 2021 - nature.com
Abstract Hydrogen sulfide (H2S), which is closely related to various cardiovascular
disorders, lowers blood pressure (BP), but whether this action is mediated via the …

Hydrogen sulfide in paraventricular nucleus enhances sympathetic activity and cardiac sympathetic afferent reflex in chronic heart failure rats

XB Gan, TY Liu, XQ Xiong, WW Chen, YB Zhou… - PLoS …, 2012 - journals.plos.org
Background Intracerebroventricular infusion of NaHS, a hydrogen sulfide (H2S) donor,
increased mean arterial pressure (MAP). This study was designed to determine the roles of …

Superoxide mediates depressive effects induced by hydrogen sulfide in rostral ventrolateral medulla of spontaneously hypertensive rats

H Yu, H Xu, X Liu, N Zhang, A He… - Oxidative Medicine and …, 2015 - Wiley Online Library
Hydrogen sulfide (H2S) plays a crucial role in the regulation of blood pressure and oxidative
stress. In the present study, we tested the hypothesis that H2S exerts its cardiovascular …

Exogenous H2S Ameliorates High Salt-Induced Hypertension by Alleviating Oxidative Stress and Inflammation in the Paraventricular Nucleus in Dahl S Rats

Y Liao, Y Fan, Q He, Y Li, D Wu, E Jiang - Cardiovascular Toxicology, 2022 - Springer
Hydrogen sulfide (H2S) is an important gaseous signaling molecule that regulates
cardiovascular activity in animals. The hypothalamic paraventricular nucleus (PVN) is a …

Exogenous hydrogen sulfide causes different hemodynamic effects in normotensive and hypertensive rats via neurogenic mechanisms

M Sikora, A Drapala, M Ufnal - Pharmacological Reports, 2014 - Elsevier
Background Increasing evidence suggests that disturbances in H 2 S homeostasis may
participate in the development of hypertension. In this study we compared hemodynamic …

Hydrogen sulfide in the rostral ventrolateral medulla inhibits sympathetic vasomotor tone through ATP-sensitive K+ channels

Q Guo, S Jin, XL Wang, R Wang, L Xiao, R He… - Journal of Pharmacology …, 2011 - ASPET
Hydrogen sulfide (H2S) acts as an endogenous gaseous transmitter in the central nervous
system and plays important roles in regulating cardiovascular function. The rostral …