Ecology-relevant bacteria drive the evolution of host antimicrobial peptides in Drosophila

MA Hanson, L Grollmus, B Lemaitre - Science, 2023 - science.org
Antimicrobial peptides are host-encoded immune effectors that combat pathogens and
shape the microbiome in plants and animals. However, little is known about how the host …

[HTML][HTML] Dynamic evolution of antimicrobial peptides underscores trade-offs between immunity and ecological fitness

MA Hanson, B Lemaitre, RL Unckless - Frontiers in Immunology, 2019 - frontiersin.org
There is a developing interest in how immune genes may function in other physiological
roles, and how traditionally non-immune peptides may, in fact, be active in immune contexts …

Molecular Population Genetics of Inducible Antibacterial Peptide Genes in Drosophila melanogaster

BP Lazzaro, AG Clark - Molecular Biology and Evolution, 2003 - academic.oup.com
Insects respond to septic infection in part by producing a suite of antimicrobial peptides that
may be subject to host-pathogen coevolutionary dynamics. In order to infer population …

[HTML][HTML] Antimicrobial peptides modulate long-term memory

R Barajas-Azpeleta, J Wu, J Gill, R Welte… - PLoS …, 2018 - journals.plos.org
Antimicrobial peptides act as a host defense mechanism and regulate the commensal
microbiome. To obtain a comprehensive view of genes contributing to long-term memory we …

Diptericin-like protein: an immune response gene regulated by the anti-bacterial gene induction pathway in Drosophila

JH Lee, KS Cho, J Lee, J Yoo, J Lee, J Chung - Gene, 2001 - Elsevier
Insects produce various anti-microbial peptides in response to injury and infection. In
Drosophila, diptericin has previously been studied as an anti-bacterial immune response …

[HTML][HTML] Antimicrobial peptides extend lifespan in Drosophila

G Loch, I Zinke, T Mori, P Carrera, J Schroer… - PLoS …, 2017 - journals.plos.org
Antimicrobial peptides (AMPs) are important defense molecules of the innate immune
system. High levels of AMPs are induced in response to infections to fight pathogens …

Antimicrobial peptides—or how our ancestors learned to control the microbiome

TCG Bosch, M Zasloff - MBio, 2021 - Am Soc Microbiol
Antimicrobial peptides (AMPs) are short and generally positively charged peptides found in
a wide variety of life forms from microorganisms to humans. Their wide range of activity …

Antimicrobial peptides keep insect endosymbionts under control

FH Login, S Balmand, A Vallier, C Vincent-Monégat… - Science, 2011 - science.org
Vertically transmitted endosymbionts persist for millions of years in invertebrates and play an
important role in animal evolution. However, the functional basis underlying the …

A genome-wide analysis of antimicrobial effector genes and their transcription patterns in Manduca sexta

Y He, X Cao, K Li, Y Hu, Y Chen, G Blissard… - Insect biochemistry and …, 2015 - Elsevier
Antimicrobial proteins/peptides (AMPs) are effectors of innate immune systems against
pathogen infection in multicellular organisms. Over half of the AMPs reported so far come …

[HTML][HTML] Convergent balancing selection on an antimicrobial peptide in Drosophila

RL Unckless, VM Howick, BP Lazzaro - Current Biology, 2016 - cell.com
Genes of the immune system often evolve rapidly and adaptively, presumably driven by
antagonistic interactions with pathogens [1–4]. Those genes encoding secreted …