CONTEXT: The perception of pain due to an acute injury or in clinical pain states undergoes
substantial processing at supraspinal levels. Supraspinal, brain mechanisms are …

Recent animal studies reveal ascending nociceptive and descending modulatory pathways
that may contribute to the affective–motivational aspects of pain and play a critical role in the …

Pain is a significant national burden in terms of patient suffering, expenditure and lost
productivity. Understanding pain is fundamental to improving evaluation, treatment and …

This selective review discusses the psychobiological mediation of nociception and pain.
Summarizing literature from physiology and neuroscience, first an overview of the …

Clinical pain is a serious public health issue. Treatment of pain-related suffering requires
knowledge of how pain signals are initially interpreted and subsequently transmitted and …

There has been a large increase in the use of brain imaging technologies to study pain.
Most likely this trend will accelerate even more in the near future. Comparing among the …

Pain is a highly complex and subjective experience that is not linearly related to the
nociceptive input. What is clear from anecdotal reports over the centuries and more recently …

Chronic pain is a frequent component of many neurological disorders, affecting 20–40% of
patients for many primary neurological diseases. These diseases result from a wide range of …

Brain processing of pain in humans is based on multiple ascending pathways and brain
regions that are involved in several pain components, such as sensory, immediate affective …

Conditioned pain modulation is a powerful analgesic mechanism, occurring when a painful
stimulus is inhibited by a second painful stimulus delivered at a different body location …