Role of the epithelial barrier in intestinal fibrosis associated with inflammatory bowel disease: relevance of the epithelial-to mesenchymal transition
DC Macias-Ceja, MT Mendoza-Ballesteros… - Frontiers in Cell and …, 2023 - frontiersin.org
In inflammatory bowel disease (IBD), chronic inflammation in the gastrointestinal tract can
lead to tissue damage and remodelling, which can ultimately result in fibrosis. Prolonged …
lead to tissue damage and remodelling, which can ultimately result in fibrosis. Prolonged …
Role of epithelial-to-mesenchymal transition in inflammatory bowel disease
Intestinal fibrosis is an inevitable complication in patients with inflammatory bowel disease
[IBD], occurring in its two major clinical manifestations: ulcerative colitis and Crohn's …
[IBD], occurring in its two major clinical manifestations: ulcerative colitis and Crohn's …
[HTML][HTML] Cellular and molecular mechanisms of intestinal fibrosis
S Speca, I Giusti, F Rieder, G Latella - World journal of …, 2012 - ncbi.nlm.nih.gov
Fibrosis is a chronic and progressive process characterized by an excessive accumulation
of extracellular matrix (ECM) leading to stiffening and/or scarring of the involved tissue …
of extracellular matrix (ECM) leading to stiffening and/or scarring of the involved tissue …
The intestinal tissue homeostasis–the role of extracellular matrix remodeling in inflammatory bowel disease
JH Mortensen, M Lindholm, LL Langholm… - Expert Review of …, 2019 - Taylor & Francis
Introduction: Extracellular matrix (ECM) remodeling of the intestinal tissue is important in
inflammatory bowel disease (IBD) due to the extensive mucosal remodeling. There are still …
inflammatory bowel disease (IBD) due to the extensive mucosal remodeling. There are still …
Stromal cell regulation of intestinal inflammatory fibrosis
Intestinal inflammatory fibrosis is a severe consequence of inflammatory bowel diseases
(IBD). There is currently no cure for the treatment of intestinal fibrosis in IBD. Although …
(IBD). There is currently no cure for the treatment of intestinal fibrosis in IBD. Although …
[HTML][HTML] Molecular basis of intestinal fibrosis in inflammatory bowel disease
A Andoh, A Nishida - Inflammatory Intestinal Diseases, 2022 - karger.com
Background: Intestinal fibrosis in Crohn's disease (CD) is considered to be irreversible and
induces persistent luminal narrowing and strictures. In the past decades, substantial …
induces persistent luminal narrowing and strictures. In the past decades, substantial …
The role of cytokine and immune responses in intestinal fibrosis
The rapidly increasing incidence of inflammatory bowel disease (IBD) in South America,
eastern Europe, Asia, and Africa has resulted in a global public health challenge. Intestinal …
eastern Europe, Asia, and Africa has resulted in a global public health challenge. Intestinal …
Current understanding of the interplay between extracellular matrix remodelling and gut permeability in health and disease
A Vilardi, S Przyborski, C Mobbs, A Rufini… - Cell Death …, 2024 - nature.com
The intestinal wall represents an interactive network regulated by the intestinal epithelium,
extracellular matrix (ECM) and mesenchymal compartment. Under healthy physiological …
extracellular matrix (ECM) and mesenchymal compartment. Under healthy physiological …
[HTML][HTML] Cellular and molecular mechanisms of intestinal fibrosis
X Wu, X Lin, J Tan, Z Liu, J He, F Hu, Y Wang… - Gut and …, 2023 - ncbi.nlm.nih.gov
Intestinal fibrosis associated stricture is a common complication of inflammatory bowel
disease usually requiring endoscopic or surgical intervention. Effective anti-fibrotic agents …
disease usually requiring endoscopic or surgical intervention. Effective anti-fibrotic agents …
Intestinal epithelium in inflammatory bowel disease
M Coskun - Frontiers in medicine, 2014 - frontiersin.org
The intestinal epithelium has a strategic position as a protective physical barrier to luminal
microbiota and actively contributes to the mucosal immune system. This barrier is mainly …
microbiota and actively contributes to the mucosal immune system. This barrier is mainly …
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