Alcohol intake remains controlled in a majority of users but becomes “compulsive,” ie,
continues despite adverse consequences, in a minority who develop alcohol addiction …

Alcohol Use Disorder (AUD) ranks among the most prevalent mental disorders, extracting~
$250 billion/year in the US alone and producing myriad medical and social harms. Also, the …

Continued seeking and drinking of alcohol despite adverse legal, health, economic, and
societal consequences is a central hallmark of human alcohol use disorders. This …

A key feature of compulsive alcohol drinking is continuing to drink despite negative
consequences. To examine the changes in neural activity that underlie this behavior …

Adolescent alcohol binge drinking constitutes a major vulnerability factor to develop
alcoholism. However, mechanisms underlying this susceptibility remain unknown. We …

Abstinence from alcohol is associated with the recruitment of neurons in the central nucleus
of the amygdala (CeA) in nondependent rats that binge drink alcohol and in alcohol …

The cellular mechanisms underlying pathological alcohol seeking remain poorly
understood. Here, we show an enhancement of nucleus accumbens (NAcb) core action …

The cortical-striatal brain circuitry is heavily implicated in drug-use. As such, the present
study investigated the functional role of cortical-striatal circuitry in modulating alcohol self …

Binge drinking is a dangerous pattern of behavior. We tested whether chronically
manipulating nucleus accumbens (NAc) activity (via clozapine-N-oxide (CNO) and Designer …

Excessive drinking to intoxication is the major behavioral characteristic of those addicted to
alcohol but it is not the only one. Indeed, individuals addicted to alcohol also crave alcoholic …