Age is the most important risk factor for neurodegeneration; however, the effects of aging
and neurodegeneration on gene expression in the human brain have most often been …

While splicing differences between tissues, sexes and species are well documented, little is
known about the extent and the nature of splicing changes that take place during human or …

Background Molecular and cellular changes are intrinsic to aging and age-related diseases.
Prior cross-sectional studies have investigated the combined effects of age and genetics on …

Here we use deep sequencing to identify sources of variation in mRNA splicing in the
dorsolateral prefrontal cortex (DLPFC) of 450 subjects from two aging cohorts. Hundreds of …

Alternative splicing (AS) is a post-transcriptional process that occurs in multiexon genes, and
errors in this process have been implicated in many human diseases. Until recently …

Alternative splicing contributes to phenotypic diversity at multiple biological scales, and its
dysregulation is implicated in both ageing and age-associated diseases in human. Cross …

Alternative splicing (AS) is a key regulatory mechanism for the development of different
tissues; however, not much is known about changes to alternative splicing during aging …

Genome-wide studies of aging have identified subsets of genes that show age-related
changes in expression. Although the types of genes that are age regulated vary among …

Pre‐mRNA splicing modulations in senescence - Meshorer - 2002 - Aging Cell - Wiley Online
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Recent studies strongly indicate that aberrations in the control of gene expression might
contribute to the initiation and progression of Alzheimer's disease (AD). In particular …