To optimally penetrate biological hydrogels such as mucus and the tumor interstitial matrix,
nanoparticles (NPs) require physicochemical properties that would typically preclude …

The impact of physical and chemical modifications of nanoparticles on their biological
function has been systemically investigated and exploited to improve their circulation and …

Mucus is a viscoelastic gel layer that typically protects exposed surfaces of the
gastrointestinal (GI) tract, lung airways, and other mucosal tissues. Particles targeted to …

Nanoparticle (NP)-bioconjugates hold great promise for more sensitive disease diagnosis
and more effective anticancer drug delivery compared with existing approaches. A critical …

To date, the role of elasticity in drug delivery remains elusive due to the inability to measure
microscale mechanics and alter rheology without affecting chemistry. Herein, we describe …

Molecular targeting of nanoparticle drug carriers promises maximized therapeutic impact to
sites of disease or injury with minimized systemic effects. Precise targeting demands …

Mucus is a viscoelastic biological hydrogel that protects the epithelial surface from
penetration by most nanoparticles, which limits the efficiency of oral drug delivery. Pursuing …

Nanoparticle (NP)‐based vehicles are attractive for biomedical delivery and therapy, owing
to improved therapeutic efficiency and reduced adverse effects compared to free drugs …

Drug delivery and cell transplantation require minimally invasive deployment strategies such
as injection through clinically relevant high‐gauge needles. Supramolecular hydrogels …

A method that could provide more uniform and longer‐lasting drug and gene delivery to
mucosal surfaces holds the potential to greatly improve the effectiveness of prophylactic and …