Block copolymer micelles target auger electron radiotherapy to the nucleus of HER2-positive breast cancer cells

B Hoang, RM Reilly, C Allen - Biomacromolecules, 2012 - ACS Publications
Intracellular trafficking of Auger electron emitting radionuclides to perinuclear and nuclear
regions of cells is critical to realizing their full therapeutic potential. In the present study …

Multifunctional Block Copolymer Micelles for the Delivery of 111In to EGFR-Positive Breast Cancer Cells for Targeted Auger Electron Radiotherapy

H Fonge, H Lee, RM Reilly, C Allen - Molecular pharmaceutics, 2010 - ACS Publications
Block copolymer micelles (BCMs) can improve the payload delivery of therapeutic agents to
tumors. Our aim was to construct hEGF-modified BCMs for the delivery of 111In to tumor …

Active targeting of block copolymer micelles with trastuzumab Fab fragments and nuclear localization signal leads to increased tumor uptake and nuclear localization …

B Hoang, SN Ekdawi, RM Reilly… - Molecular …, 2013 - ACS Publications
Block copolymer micelles (BCMs) have been employed as effective drug delivery systems to
solid tumors by virtue of their capacity to transport large therapeutic payloads and passively …

Targeted radionuclide therapy using auger electron emitters: the quest for the right vector and the right radionuclide

MB Idrissou, A Pichard, B Tee, T Kibedi, S Poty… - Pharmaceutics, 2021 - mdpi.com
Auger electron emitters (AEEs) are attractive tools in targeted radionuclide therapy to
specifically irradiate tumour cells while sparing healthy tissues. However, because of their …

Trastuzumab Labeled to High Specific Activity with 111In by Site-Specific Conjugation to a Metal-Chelating Polymer Exhibits Amplified Auger Electron-Mediated …

G Ngo Ndjock Mbong, Y Lu, C Chan, Z Cai… - Molecular …, 2015 - ACS Publications
Our objective was to evaluate the cytotoxicity toward HER2-positive human breast cancer
(BC) cells of trastuzumab modified site− specifically with a metal-chelating polymer (MCP) …

In vitro evaluation and biodistribution of HER2-targeted liposomes loaded with an 125I-labelled DNA-intercalator

A Fondell, K Edwards, J Unga, E Kullberg… - Journal of drug …, 2011 - Taylor & Francis
Background: Increasing attention is currently focussed on the issue of finding strategies for
the delivery of Auger-electron-emitting radionuclides into tumor cell nuclei. Purpose: In this …

Intracellular routing in breast cancer cells of streptavidin-conjugated trastuzumab Fab fragments linked to biotinylated doxorubicin-functionalized metal chelating …

P Liu, Z Cai, JW Kang, AJ Boyle, J Adams… - …, 2014 - ACS Publications
We describe the synthesis of a heterotelechelic metal-chelating polymer (Bi-MCP-Dox), a
polyacrylamide with a number average degree of polymerization DPn= 50 (PDI= 1.2), with …

[HTML][HTML] In vitro cytotoxicity of Auger electron-emitting [67Ga] Ga-trastuzumab

MF bin Othman, E Verger, I Costa… - Nuclear medicine and …, 2020 - Elsevier
Introduction Molecular radiotherapy exploiting short-range Auger electron-emitting
radionuclides has potential for targeted cancer treatment and, in particular, is an attractive …

Au@ Pt core-shell nanoparticle bioconjugates for the therapy of HER2+ breast cancer and hepatocellular carcinoma. Model studies on the applicability of 193mPt and …

K Wawrowicz, A Majkowska-Pilip, D Gaweł, E Chajduk… - Molecules, 2021 - mdpi.com
193mPt and 195mPt radionuclides are therapeutically attractive Auger electron emitters with
notably high Auger electron yield per decay. The present paper summarizes the first step of …

111In-labeled trastuzumab (Herceptin) modified with nuclear localization sequences (NLS): an Auger electron-emitting radiotherapeutic agent for HER2/neu-amplified …

DL Costantini, C Chan, Z Cai, KA Vallis… - Journal of Nuclear …, 2007 - Soc Nuclear Med
The cytotoxicity and tumor-targeting properties of the anti-HER2/neu monoclonal antibody
trastuzumab modified with peptides (CGYG PKKKRKV GG) harboring the nuclear …