Block copolymer micelles target auger electron radiotherapy to the nucleus of HER2-positive breast cancer cells
Intracellular trafficking of Auger electron emitting radionuclides to perinuclear and nuclear
regions of cells is critical to realizing their full therapeutic potential. In the present study …
regions of cells is critical to realizing their full therapeutic potential. In the present study …
Multifunctional Block Copolymer Micelles for the Delivery of 111In to EGFR-Positive Breast Cancer Cells for Targeted Auger Electron Radiotherapy
Block copolymer micelles (BCMs) can improve the payload delivery of therapeutic agents to
tumors. Our aim was to construct hEGF-modified BCMs for the delivery of 111In to tumor …
tumors. Our aim was to construct hEGF-modified BCMs for the delivery of 111In to tumor …
Active targeting of block copolymer micelles with trastuzumab Fab fragments and nuclear localization signal leads to increased tumor uptake and nuclear localization …
B Hoang, SN Ekdawi, RM Reilly… - Molecular …, 2013 - ACS Publications
Block copolymer micelles (BCMs) have been employed as effective drug delivery systems to
solid tumors by virtue of their capacity to transport large therapeutic payloads and passively …
solid tumors by virtue of their capacity to transport large therapeutic payloads and passively …
Targeted radionuclide therapy using auger electron emitters: the quest for the right vector and the right radionuclide
Auger electron emitters (AEEs) are attractive tools in targeted radionuclide therapy to
specifically irradiate tumour cells while sparing healthy tissues. However, because of their …
specifically irradiate tumour cells while sparing healthy tissues. However, because of their …
Trastuzumab Labeled to High Specific Activity with 111In by Site-Specific Conjugation to a Metal-Chelating Polymer Exhibits Amplified Auger Electron-Mediated …
Our objective was to evaluate the cytotoxicity toward HER2-positive human breast cancer
(BC) cells of trastuzumab modified site− specifically with a metal-chelating polymer (MCP) …
(BC) cells of trastuzumab modified site− specifically with a metal-chelating polymer (MCP) …
In vitro evaluation and biodistribution of HER2-targeted liposomes loaded with an 125I-labelled DNA-intercalator
A Fondell, K Edwards, J Unga, E Kullberg… - Journal of drug …, 2011 - Taylor & Francis
Background: Increasing attention is currently focussed on the issue of finding strategies for
the delivery of Auger-electron-emitting radionuclides into tumor cell nuclei. Purpose: In this …
the delivery of Auger-electron-emitting radionuclides into tumor cell nuclei. Purpose: In this …
Intracellular routing in breast cancer cells of streptavidin-conjugated trastuzumab Fab fragments linked to biotinylated doxorubicin-functionalized metal chelating …
We describe the synthesis of a heterotelechelic metal-chelating polymer (Bi-MCP-Dox), a
polyacrylamide with a number average degree of polymerization DPn= 50 (PDI= 1.2), with …
polyacrylamide with a number average degree of polymerization DPn= 50 (PDI= 1.2), with …
[HTML][HTML] In vitro cytotoxicity of Auger electron-emitting [67Ga] Ga-trastuzumab
MF bin Othman, E Verger, I Costa… - Nuclear medicine and …, 2020 - Elsevier
Introduction Molecular radiotherapy exploiting short-range Auger electron-emitting
radionuclides has potential for targeted cancer treatment and, in particular, is an attractive …
radionuclides has potential for targeted cancer treatment and, in particular, is an attractive …
Au@ Pt core-shell nanoparticle bioconjugates for the therapy of HER2+ breast cancer and hepatocellular carcinoma. Model studies on the applicability of 193mPt and …
K Wawrowicz, A Majkowska-Pilip, D Gaweł, E Chajduk… - Molecules, 2021 - mdpi.com
193mPt and 195mPt radionuclides are therapeutically attractive Auger electron emitters with
notably high Auger electron yield per decay. The present paper summarizes the first step of …
notably high Auger electron yield per decay. The present paper summarizes the first step of …
111In-labeled trastuzumab (Herceptin) modified with nuclear localization sequences (NLS): an Auger electron-emitting radiotherapeutic agent for HER2/neu-amplified …
DL Costantini, C Chan, Z Cai, KA Vallis… - Journal of Nuclear …, 2007 - Soc Nuclear Med
The cytotoxicity and tumor-targeting properties of the anti-HER2/neu monoclonal antibody
trastuzumab modified with peptides (CGYG PKKKRKV GG) harboring the nuclear …
trastuzumab modified with peptides (CGYG PKKKRKV GG) harboring the nuclear …