Targeting the NLRP3 inflammasome in cardiovascular diseases

S Toldo, E Mezzaroma, LF Buckley, N Potere… - Pharmacology & …, 2022 - Elsevier
The NACHT, leucine-rich repeat (LRR), and pyrin domain (PYD)-containing protein 3
(NLRP3) inflammasome is an intracellular sensing protein complex that plays a major role in …

[HTML][HTML] NLRP3 inflammasome inhibitors in cardiovascular diseases

E Mezzaroma, A Abbate, S Toldo - Molecules, 2021 - mdpi.com
Virtually all types of cardiovascular diseases are associated with pathological activation of
the innate immune system. The NACHT, leucine-rich repeat (LRR), and pyrin domain (PYD) …

Targeting NLRP3 (nucleotide-binding domain, leucine-rich–containing family, pyrin domain–containing-3) inflammasome in cardiovascular disorders

Z Wang, W Hu, C Lu, Z Ma, S Jiang, C Gu… - … , and vascular biology, 2018 - Am Heart Assoc
Inflammation is an important innate immune response to infection or tissue damage.
Inflammasomes are involved in the onset and development of inflammation. The NLRP3 …

Spotlight on NLRP3 inflammasome: role in pathogenesis and therapies of atherosclerosis

C Jiang, S Xie, G Yang, N Wang - Journal of Inflammation …, 2021 - Taylor & Francis
Inflammation is an intricate biological response of body tissues to detrimental stimuli.
Cardiovascular disease (CVD) is the leading cause of death worldwide, and inflammation is …

[HTML][HTML] NLRP3 inflammasome: The rising star in cardiovascular diseases

Y Zheng, L Xu, N Dong, F Li - Frontiers in Cardiovascular Medicine, 2022 - frontiersin.org
Cardiovascular diseases (CVDs) are the prevalent cause of mortality around the world.
Activation of inflammasome contributes to the pathological progression of cardiovascular …

NLRP3 inflammasome, an immune‐inflammatory target in pathogenesis and treatment of cardiovascular diseases

Y Wang, X Liu, H Shi, Y Yu, Y Yu, M Li… - Clinical and …, 2020 - Wiley Online Library
Inflammation is an important process involved in several cardiovascular diseases (CVDs),
and nod‐like receptor family pyrin domain containing 3 (NLRP3) inflammasome is a vital …

Role of NLRP3 inflammasome in the pathogenesis of cardiovascular diseases

D Liu, X Zeng, X Li, JL Mehta, X Wang - Basic research in cardiology, 2018 - Springer
NLRP3 inflammasome is a key multiprotein signaling platform that tightly controls
inflammatory responses and coordinates antimicrobial host defenses by activating caspase …

[HTML][HTML] Regulatory mechanisms of the NLRP3 inflammasome, a novel immune-inflammatory marker in cardiovascular diseases

N An, Y Gao, Z Si, H Zhang, L Wang, C Tian… - Frontiers in …, 2019 - frontiersin.org
The nod-like receptor family pyrin domain containing 3 (NLRP3) is currently the most widely
studied inflammasome and has become a hot topic of recent research. As a macromolecular …

NLRP3: a novel mediator in cardiovascular disease

W Zhou, C Chen, Z Chen, L Liu, J Jiang… - Journal of …, 2018 - Wiley Online Library
Cardiovascular disease is a major cause of death worldwide. Inflammasome infiltration has
been identified to play a central role in the pathological progression of certain …

NLRP3 inflammasome in cardiovascular diseases: pathophysiological and pharmacological implications

C Pellegrini, A Martelli, L Antonioli… - Medicinal Research …, 2021 - Wiley Online Library
Growing evidence points out the importance of nucleotide‐binding oligomerization domain
leucine‐rich repeat and pyrin domain‐containing protein 3 (NLRP3) inflammasome in the …