抄録 To determine the relative contribution of obesity and visceral white adipose tissue
(WAT) to metabolic syndrome, we developed a model that is susceptible to high-fat diet …

Obesity, an abnormal condition of adipose tissue, has recently been recognized as a major
cause of metabolic syndromes, especially non-alcoholic fatty liver disease (NAFLD). The …

Severe adipose tissue deficiency (lipoatrophy) causes insulin-resistant diabetes, elevated
serum triglyceride and fatty acid levels, and massive triglyceride deposition in the liver. In …

Visceral fat accumulation is accompanied by several metabolic disorders. Here, we
investigate the improvement of visceral fat accumulation in the early phase of diet …

Background Adverse effects of high-fat diets (HFD) on metabolic homeostasis are linked to
adipose tissue dysfunction. The goal of this study was to examine the effect of the HFD …

Although obesity is a major background of life style-related diseases such as diabetes
mellitus, lipid disorder, hypertension and cardiovascular disease, the extent of whole body …

Excess caloric intake can lead to insulin resistance. The underlying reasons are complex but
likely related to ectopic lipid deposition in nonadipose tissue. We hypothesized that the …

The effects of high-fat feeding on the development of obesity were evaluated in intercellular
adhesion molecule-1 (ICAM-1) knockout and C57BL/6J (B6) male mice fed a high-fat diet …

Background: Enlargement of adipocytes from subcutaneous abdominal adipose tissue
(SAT), increased intrahepatic lipid content (IHL), intramyocellular lipid content (IMCL), and …

Obese (fa/fa) Zucker rat is a spontaneous genetic obesity model and, by comparison with
lean Zucker rat, exhibits hyperphagia, hyperinsulinemia, and hyperlipidemia. The aim of this …