Genomes are characterized by large regions of homogeneous base compositions known as
isochores. The latter are divided into GC-poor and GC-rich classes linked to distinct …

Background The availability of fully sequenced genomes and the implementation of
transcriptome technologies have increased the studies investigating the expression profiles …

Several studies on adult tissues agree on the presence of a positive effect of the genomic
and genic base composition on mammalian gene expression. Recent literature supports the …

In an article published in these pages, Elhaik et al.(Elhaik E, Landan G, Graur D. 2009. Can
GC content at third-codon positions be used as a proxy for isochore composition? Mol Biol …

The isochore theory depicts the genomes of warm-blooded vertebrates as a mosaic of long
genomic regions that are characterized by relatively homogeneous GC content. In the …

The human genome is a mosaic of isochores, which are long (> 200 kb) DNA sequences
that are fairly homogeneous in base composition and can be assigned to five families …

Isochores are large DNA segments (≫ 300 kb on average) that are characterized by an
internal variation in GC well below the full variation seen in the mammalian genome …

The human genome is composed of large sequence segments with fairly homogeneous GC
content, namely isochores, which have been linked to many important functions; biological …

In a recent paper in these pages, Cohen et al. search for isochores in the human genome,
based on a system of attributes that they assign to isochores. The putative isochores that …

Background Previous work from our laboratory showed that (i) vertebrate genomes are
mosaics of isochores, typically megabase-size DNA segments that are fairly homogeneous …