To assess whether pseudoradicular low-back pain may be associated with subclinical
sensory deficits in the distal extremity, we applied the quantitative sensory testing protocol of …

The present study investigated the neuropathic components of chronic low back pain (LBP)
in patients with and without lower limb pain using the DN4 questionnaire and confirmed its …

Objectives: Whether chronic localized pain (CLP) and chronic widespread pain (CWP) have
different mechanisms or to what extent they overlap in their pathophysiology is controversial …

Chronic low back pain (CLBP) was shown to be associated with pathophysiological
changes at several levels of the sensorimotor system. Changes in sensory thresholds have …

Chronic low back pain is highly prevalent in Western societies. Large epidemiological
studies show that 20% to 35% of patients with back pain suffer from a neuropathic pain …

It has been proposed that patients with chronic non-specific low back pain (CNSLBP) can be
broadly classified based on clinical features that represent either predominantly a …

Background Adequate pain assessment is critical for evaluating the efficacy of analgesic
treatment in clinical practice and during the development of new therapies. Yet the currently …

Background Mechanical quantitative sensory testing (QST) assesses sensory functioning
and detects functional changes in (central) nociceptive processing. It has been hypothesized …

Objectives Alterations in the central nervous system leading to higher pain sensitivity have
been shown in both chronic back pain (CBP) and fibromyalgia syndrome (FMS). The aim of …

Low back pain is a widespread debilitating problem with a lifetime prevalence of 80%, with
the underlying pain mechanism unknown in approximately 90% of cases. We used the …