The brain has almost no energy reserve, but its activity coordinates organismal function, a
burden that requires precise coupling between neurotransmission and energy metabolism …

Astrocytes play key roles in the regulation of brain energy metabolism, which has a major
impact on brain functions, including memory, neuroprotection, resistance to oxidative stress …

Glucose, glycogen, and lactate are traditionally identified with brain energetics, ATP
turnover, and pathophysiology. However, recent studies extend their roles to include …

As part of the blood-brain-barrier, astrocytes are ideally positioned between cerebral
vasculature and neuronal synapses to mediate nutrient uptake from the systemic circulation …

Dynamic adjustments to neuronal energy supply in response to synaptic activity are critical
for neuronal function. Glial cells known as astrocytes have processes that ensheath most …

In recent years, previously unsuspected roles of astrocytes have been revealed, largely
owing to the development of new tools enabling their selective study in situ. These exciting …

Brain energy metabolism has been the object of intense research in recent years.
Pioneering work has identified the different cell types involved in energy production and use …

Understanding brain energy metabolism—neuroenergetics—is becoming increasingly
important as it can be identified repeatedly as the source of neurological perturbations …

Astrocytic energy demand is stimulated by K+ and glutamate uptake, signaling processes,
responses to neurotransmitters, Ca2+ fluxes, and filopodial motility. Astrocytes derive energy …

Neuronal activity is a high‐energy demanding process recruiting all neural cells that adapt
their metabolism to sustain the energy and redox balance of neurons. During …