Recent investigations have revealed that changes in DNA methylation status play an
important role in aging-associated pathologies and lifespan. The methylation of DNA is …

The polyamines spermidine and spermine are synthesized in almost all organisms and are
also contained in food. Polyamine synthesis decreases with aging, but no significant …

Polyamines, spermidine and spermine, are synthesized in every living cell and are therefore
contained in foods, especially in those that are thought to contribute to health and longevity …

Polyamines (spermine and spermidine) play many important roles in cellular function and
are supplied from the intestinal lumen. We have shown that continuous high polyamine …

The Japanese diet and the Mediterranean diet are rich in polyamines (spermidine and
spermine). Increased polyamine intake elevated blood spermine levels, inhibited aging …

The polyamines spermidine and spermine are positively charged aliphatic molecules. They
are critical in the regulation of nucleic acid and protein structures, protein synthesis, protein …

DNA methylation reactions are regulated, in the first instance, by enzymes and the
intermediates that constitute the 'so called'one-carbon metabolism. This is a complex …

Polyamines are polycations that interact with negatively charged molecules such as DNA,
RNA and proteins. They play multiple roles in cell growth, survival and proliferation …

Alterations in enzymatic activities underlying the cellular capacity to maintain functional S-
adenosylmethionine (SAM) cycle are associated with modified levels of its constituents …

Methylation of genomic cytosines is one of the best characterized epigenetic mechanisms,
and investigation of its relationship with other biochemical pathways represents a critical …