Background The spleen plays a critical role in the immune response against malaria
parasite infection, where splenic fibroblasts (SFs) are abundantly present and contribute to …

Plasmodium vivax is the most widespread human malaria parasite. The spleen is one of the
most significant immune organs in the course of Plasmodium infection, and it contains …

Proteins present on the surface of malaria parasites that participate in the process of
invasion and adhesion to host cells are considered attractive vaccine targets. Aided by the …

Abstract Background Malaria caused by Plasmodium vivax is a major public health problem
worldwide that affects 70-80 million people in the Middle East, Asia, Western Pacific, South …

Background: Plasmodium tryptophan-rich (TR) proteins have been proposed as potential
vaccine candidate antigens. Among them, P. vivax tryptophan-rich antigens (PvTR-Ags) …

Objective: Plasmodium spp. merozoite glycosylphosphatidylinositol-anchored proteins (GPI-
APs) considered as protective immunogen in novel vaccines against malaria. To analyze the …

Plasmodium vivax-infected erythrocytes can enter the spleen and evade spleen clearance to
establish chronic infections. However, the mechanism underlying P. vivax immune evasion …

Plasmodium vivax thrombospondin-related anonymous protein (PvTRAP) is a promising
malaria vaccine candidate; however, it exhibits sequence heterogeneity. Therefore, to …

Cerebral malaria (CM) is a major cause of death due to Plasmodium infection. Both parasite
and host factors contribute to the onset of CM, but the precise cellular and molecular …

The Plasmodium parasite has to cross various immunological barriers for successful
infection. Parasites have evolved mechanisms to evade host immune responses, which …