Endogenous kappa-opioid mediation of stress-induced potentiation of ethanol-conditioned place preference and self-administration
Rationale Exposure to inescapable stressors increases both the rewarding properties and
self-administration of cocaine through the signaling of the kappa-opioid receptor (KOR), but …
self-administration of cocaine through the signaling of the kappa-opioid receptor (KOR), but …
Behavioral stress may increase the rewarding valence of cocaine-associated cues through a dynorphin/κ-opioid receptor-mediated mechanism without affecting …
AG Schindler, S Li, C Chavkin - Neuropsychopharmacology, 2010 - nature.com
Stress exposure increases the risk of addictive drug use in human and animal models of
drug addiction by mechanisms that are not completely understood. Mice subjected to …
drug addiction by mechanisms that are not completely understood. Mice subjected to …
Stress-induced enhancement of ethanol intake in C57BL/6J mice with a history of chronic ethanol exposure: involvement of kappa opioid receptors
RI Anderson, MF Lopez, HC Becker - Frontiers in cellular …, 2016 - frontiersin.org
Our laboratory has previously demonstrated that daily forced swim stress (FSS) prior to
ethanol drinking sessions facilitates enhanced ethanol consumption in mice with a history of …
ethanol drinking sessions facilitates enhanced ethanol consumption in mice with a history of …
κ opioid receptor antagonism and prodynorphin gene disruption block stress-induced behavioral responses
JP McLaughlin, M Marton-Popovici… - Journal of …, 2003 - Soc Neuroscience
Previous studies have demonstrated that stress may increase prodynorphin gene
expression, and κ opioid agonists suppress drug reward. Therefore, we tested the …
expression, and κ opioid agonists suppress drug reward. Therefore, we tested the …
Prior activation of kappa opioid receptors by U50, 488 mimics repeated forced swim stress to potentiate cocaine place preference conditioning
Repeated forced-swim stress (FSS) produced analgesia, immobility and potentiation of
cocaine-conditioned place preference (CPP) in wild-type C57Bl/6 mice, but not in littermates …
cocaine-conditioned place preference (CPP) in wild-type C57Bl/6 mice, but not in littermates …
Exposure to chronic mild stress prevents kappa opioid-mediated reinstatement of cocaine and nicotine place preference
Stress increases the risk of drug abuse, causes relapse to drug seeking, and potentiates the
rewarding properties of both nicotine and cocaine. Understanding the mechanisms by which …
rewarding properties of both nicotine and cocaine. Understanding the mechanisms by which …
Stress-induced reinstatement of cocaine seeking is mediated by the kappa opioid system
VA Redila, C Chavkin - Psychopharmacology, 2008 - Springer
Introduction Prior activation of the kappa opioid system by repeated stress or agonist
administration has been previously shown to potentiate the rewarding properties of …
administration has been previously shown to potentiate the rewarding properties of …
Kappa opioid regulation of depressive-like behavior during acute withdrawal and protracted abstinence from ethanol
SK Jarman, AM Haney, GR Valdez - PloS one, 2018 - journals.plos.org
The dynorphin/kappa opioid receptor (DYN/KOR) system appears to be a key mediator of
the behavioral effects of chronic exposure to alcohol. Although KOR opioid receptor …
the behavioral effects of chronic exposure to alcohol. Although KOR opioid receptor …
Activation of the kappa opioid receptor in the dorsal raphe nucleus mediates the aversive effects of stress and reinstates drug seeking
BB Land, MR Bruchas, S Schattauer… - Proceedings of the …, 2009 - National Acad Sciences
Although stress has profound effects on motivated behavior, the underlying mechanisms
responsible are incompletely understood. In this study we elucidate a functional pathway in …
responsible are incompletely understood. In this study we elucidate a functional pathway in …
Social defeat stress-induced behavioral responses are mediated by the endogenous kappa opioid system
JP McLaughlin, S Li, J Valdez, TA Chavkin… - …, 2006 - nature.com
Previous studies have demonstrated that repeated forced-swim stress-induced behaviors
(including analgesia, immobility, and increased drug reward) were mediated by the release …
(including analgesia, immobility, and increased drug reward) were mediated by the release …