Rationale Exposure to inescapable stressors increases both the rewarding properties and
self-administration of cocaine through the signaling of the kappa-opioid receptor (KOR), but …

Stress exposure increases the risk of addictive drug use in human and animal models of
drug addiction by mechanisms that are not completely understood. Mice subjected to …

Our laboratory has previously demonstrated that daily forced swim stress (FSS) prior to
ethanol drinking sessions facilitates enhanced ethanol consumption in mice with a history of …

Previous studies have demonstrated that stress may increase prodynorphin gene
expression, and κ opioid agonists suppress drug reward. Therefore, we tested the …

Repeated forced-swim stress (FSS) produced analgesia, immobility and potentiation of
cocaine-conditioned place preference (CPP) in wild-type C57Bl/6 mice, but not in littermates …

Stress increases the risk of drug abuse, causes relapse to drug seeking, and potentiates the
rewarding properties of both nicotine and cocaine. Understanding the mechanisms by which …

Introduction Prior activation of the kappa opioid system by repeated stress or agonist
administration has been previously shown to potentiate the rewarding properties of …

The dynorphin/kappa opioid receptor (DYN/KOR) system appears to be a key mediator of
the behavioral effects of chronic exposure to alcohol. Although KOR opioid receptor …

Although stress has profound effects on motivated behavior, the underlying mechanisms
responsible are incompletely understood. In this study we elucidate a functional pathway in …

Previous studies have demonstrated that repeated forced-swim stress-induced behaviors
(including analgesia, immobility, and increased drug reward) were mediated by the release …