Using the collaborative cross to identify the role of host genetics in defining the murine gut microbiome

A Nagarajan, K Scoggin, J Gupta, DW Threadgill… - Microbiome, 2023 - Springer
Background The human gut microbiota is a complex community comprised of trillions of
bacteria and is critical for the digestion and absorption of nutrients. Bacterial communities of …

Host genetic and environmental effects on mouse intestinal microbiota

JH Campbell, CM Foster, T Vishnivetskaya… - The ISME …, 2012 - academic.oup.com
The mammalian gut harbors complex and variable microbial communities, across both host
phylogenetic space and conspecific individuals. A synergy of host genetic and …

Murine genetic background has a stronger impact on the composition of the gut microbiota than maternal inoculation or exposure to unlike exogenous microbiota

H Korach-Rechtman, S Freilich… - Applied and …, 2019 - Am Soc Microbiol
The gut microbiota is a complex ecosystem, affected by both environmental factors and host
genetics. Here, we aim at uncovering the bacterial taxa whose gut persistence is controlled …

Taxonomic composition and variation in the gut microbiota of laboratory mice

J Yang, J Chun - Mammalian Genome, 2021 - Springer
The gut microbiota can affect host health, including humans. Mouse models have been used
extensively to study the relationships between the host and the gut microbiota. With the …

Inflammation-associated enterotypes, host genotype, cage and inter-individual effects drive gut microbiota variation in common laboratory mice

F Hildebrand, TLA Nguyen, B Brinkman, RG Yunta… - Genome biology, 2013 - Springer
Background Murine models are a crucial component of gut microbiome research.
Unfortunately, a multitude of genetic backgrounds and experimental setups, together with …

Individuality in gut microbiota composition is a complex polygenic trait shaped by multiple environmental and host genetic factors

AK Benson, SA Kelly, R Legge, F Ma… - Proceedings of the …, 2010 - National Acad Sciences
In vertebrates, including humans, individuals harbor gut microbial communities whose
species composition and relative proportions of dominant microbial groups are …

Impact of host genetics on gut microbiome: Take‐home lessons from human and mouse studies

I Cahana, FA Iraqi - Animal models and experimental medicine, 2020 - Wiley Online Library
The intestinal microbiome has emerged as an important component involved in various
diseases. Therefore, the interest in understanding the factors shaping its composition is …

Identifying gut microbe–host phenotype relationships using combinatorial communities in gnotobiotic mice

JJ Faith, PP Ahern, VK Ridaura, J Cheng… - Science translational …, 2014 - science.org
Identifying a scalable, unbiased method for discovering which members of the human gut
microbiota influence specific physiologic, metabolic, and immunologic phenotypes remains …

Murine gut microbiota is defined by host genetics and modulates variation of metabolic traits

AM McKnite, ME Perez-Munoz, L Lu, EG Williams… - PloS one, 2012 - journals.plos.org
The gastrointestinal tract harbors a complex and diverse microbiota that has an important
role in host metabolism. Microbial diversity is influenced by a combination of environmental …

The Mouse Gastrointestinal Bacteria Catalogue enables translation between the mouse and human gut microbiotas via functional mapping

BS Beresford-Jones, SC Forster, MD Stares, G Notley… - Cell host & …, 2022 - cell.com
Human health and disease have increasingly been shown to be impacted by the gut
microbiota, and mouse models are essential for investigating these effects. However, the …