Metastatic dissemination occurs very early in the malignant progression of a cancer but the
clinical manifestation of metastases often takes years. In recent decades, 5-year survival of …

Metastasis is the leading cause of cancer death. The metastatic cascade is a complex yet
inefficient process that we have only begun to understand in recent years. Several of the …

Most cancer deaths are due to the development of metastases, hence the most important
improvements in morbidity and mortality will result from prevention (or elimination) of such …

Metastatic dissemination with subsequent clinical outgrowth leads to the greatest part of
morbidity and mortality from most solid tumors. Even more daunting is that many of these …

Most cancer-associated deaths result from metastasis. However, it remains unknown
whether the size, microenvironment or other features of a metastatic lesion dictate its …

Metastatic disease is the culmination of cancer and its most common life-threatening
manifestation. The highly complex process by which cancer cells disseminate to and …

Despite recent progress in gene-expression profiling studies, the biology underlying the
various patterns of metastasis that are observed in different tumour types remains unclear …

Metastasis, the life‐threatening aspect of cancer, is a systemic disease process.
Considerable progress has been made in recent years regarding how tumor cells circulating …

Despite considerable advancements that shattered previously held dogmas about the
metastatic cascade, the evolution of therapies to treat metastatic disease has not kept up. In …

Metastases are responsible for the vast majority of cancer-related deaths, but, despite
intense efforts to understand their underlying mechanisms with the goal of uncovering …