The hippocampus in aging and disease: from plasticity to vulnerability

T Bartsch, P Wulff - Neuroscience, 2015 - Elsevier
The hippocampus has a pivotal role in learning and in the formation and consolidation of
memory and is critically involved in the regulation of emotion, fear, anxiety, and stress …

Structural plasticity and hippocampal function

B Leuner, E Gould - Annual review of psychology, 2010 - annualreviews.org
The hippocampus is a region of the mammalian brain that shows an impressive capacity for
structural reorganization. Preexisting neural circuits undergo modifications in dendritic …

Impact of neuroinflammation on hippocampal neurogenesis: relevance to aging and Alzheimer's disease

J Valero, L Bernardino, FL Cardoso… - Journal of …, 2017 - content.iospress.com
The cognitive reserve is associated with the capacity of the brain to maintain cognitive
performance in spite of being challenged by stressful degenerative insults related to aging …

A pathophysiological framework of hippocampal dysfunction in ageing and disease

SA Small, SA Schobel, RB Buxton, MP Witter… - Nature Reviews …, 2011 - nature.com
The hippocampal formation has been implicated in a growing number of disorders, from
Alzheimer's disease and cognitive ageing to schizophrenia and depression. How can the …

Hippocampal plasticity during the progression of Alzheimer's disease

EJ Mufson, L Mahady, D Waters, SE Counts, SE Perez… - Neuroscience, 2015 - Elsevier
Neuroplasticity involves molecular and structural changes in central nervous system (CNS)
throughout life. The concept of neural organization allows for remodeling as a compensatory …

Structural plasticity of the hippocampus in neurodegenerative diseases

PDE Weerasinghe-Mudiyanselage, MJ Ang… - International journal of …, 2022 - mdpi.com
Neuroplasticity is the capacity of neural networks in the brain to alter through development
and rearrangement. It can be classified as structural and functional plasticity. The …

Aging, stress and the hippocampus

DB Miller, JP O'callaghan - Ageing research reviews, 2005 - Elsevier
Functional loss often occurs in many body systems (eg, endocrine, cognitive, motor) with the
passage of years, but there is great individual variation in the degree of compromise shown …

The emerging role of the interplay among astrocytes, microglia, and neurons in the hippocampus in health and disease

D Lana, F Ugolini, D Nosi, GL Wenk… - Frontiers in aging …, 2021 - frontiersin.org
For over a century, neurons have been considered the basic functional units of the brain
while glia only elements of support. Activation of glia has been long regarded detrimental for …

The effects of aging in the hippocampus and cognitive decline

LEB Bettio, L Rajendran, J Gil-Mohapel - Neuroscience & Biobehavioral …, 2017 - Elsevier
Aging is a natural process that is associated with cognitive decline as well as functional and
social impairments. One structure of particular interest when considering aging and …

The effects of hormones and physical exercise on hippocampal structural plasticity

J Triviño-Paredes, AR Patten, J Gil-Mohapel… - Frontiers in …, 2016 - Elsevier
The hippocampus plays an integral role in certain aspects of cognition. Hippocampal
structural plasticity and in particular adult hippocampal neurogenesis can be influenced by …