The concept that adenine and uridine nucleotides function as extracellular signaling
molecules has been markedly expanded in the last decade. At least 15 nucleotide-activated …

The occurrence of a physiologically relevant release of adenine nucleotides that results in
the activation of cell surface receptors was formally postulated several decades ago',?. More …

Extracellular nucleotides and nucleosides mediate diverse signaling effects in virtually all
organs and tissues. Most models of purinergic signaling depend on functional interactions …

There is now wide acceptance that ATP and other nucleotides are ubiquitous extracellular
chemical messengers. ATP and diadenosine polyphosphates can be released from …

Nucleotides are important extracellular signaling molecules. At least five mammalian P2Y
receptors exist that are specifically activated by ATP, UTP, ADP, or UDP. Although the …

Nucleotides are ubiquitous intercellular messengers whose actions are mediated by specific
receptors. Since the first clonings in 1993, it is known that nucleotide receptors belong to two …

Within the past 10 years the field of signaling via extracellular nucleotides has witnessed a
breath-taking expansion. Molecular cloning of receptors and physiological and …

Extracellular ATP, at micromolar concentrations, induces significant functional changes in a
wide variety of cells and tissues. ATP can be released from the cytosol of damaged cells or …

Extracellular nucleotides, mainly ATP, but also ADP, UTP, UDP and UDP-sugars,
adenosine, and adenine base participate in the “purinergic signalling” pathway, an …

P2 receptors for extracellular nucleotides are divided into two categories: the ion channel
receptors (P2X) and the G-protein-coupled receptors (P2Y). For the P2X receptors, signal …