[HTML][HTML] Calcium transients on the ER surface trigger liquid-liquid phase separation of FIP200 to specify autophagosome initiation sites
Q Zheng, Y Chen, D Chen, H Zhao, Y Feng, Q Meng… - Cell, 2022 - cell.com
The mechanism that initiates autophagosome formation on the ER in multicellular organisms
is elusive. Here, we showed that autophagy stimuli trigger Ca 2+ transients on the outer …
is elusive. Here, we showed that autophagy stimuli trigger Ca 2+ transients on the outer …
[HTML][HTML] The ER-localized transmembrane protein EPG-3/VMP1 regulates SERCA activity to control ER-isolation membrane contacts for autophagosome formation
During autophagosome formation in mammalian cells, isolation membranes (IMs;
autophagosome precursors) dynamically contact the ER. Here, we demonstrated that the ER …
autophagosome precursors) dynamically contact the ER. Here, we demonstrated that the ER …
ER–plasma membrane contact sites contribute to autophagosome biogenesis by regulation of local PI 3P synthesis
AC Nascimbeni, F Giordano, N Dupont, D Grasso… - The EMBO …, 2017 - embopress.org
The double‐membrane‐bound autophagosome is formed by the closure of a structure
called the phagophore, origin of which is still unclear. The endoplasmic reticulum (ER) is …
called the phagophore, origin of which is still unclear. The endoplasmic reticulum (ER) is …
[HTML][HTML] The ER contact proteins VAPA/B interact with multiple autophagy proteins to modulate autophagosome biogenesis
YG Zhao, N Liu, G Miao, Y Chen, H Zhao, H Zhang - Current Biology, 2018 - cell.com
The endoplasmic reticulum (ER) is the site of biogenesis of the isolation membrane (IM,
autophagosome precursor) and forms extensive contacts with IMs during their expansion …
autophagosome precursor) and forms extensive contacts with IMs during their expansion …
ER exit sites are physical and functional core autophagosome biogenesis components
M Graef, JR Friedman, C Graham… - Molecular biology of …, 2013 - Am Soc Cell Biol
Autophagy is a central homeostasis and stress response pathway conserved in all
eukaryotes. One hallmark of autophagy is the de novo formation of autophagosomes. These …
eukaryotes. One hallmark of autophagy is the de novo formation of autophagosomes. These …
[HTML][HTML] Super-assembly of ER-phagy receptor Atg40 induces local ER remodeling at contacts with forming autophagosomal membranes
K Mochida, A Yamasaki, K Matoba, H Kirisako… - Nature …, 2020 - nature.com
The endoplasmic reticulum (ER) is selectively degraded by autophagy (ER-phagy) through
proteins called ER-phagy receptors. In Saccharomyces cerevisiae, Atg40 acts as an ER …
proteins called ER-phagy receptors. In Saccharomyces cerevisiae, Atg40 acts as an ER …
[HTML][HTML] A new type of ERGIC–ERES membrane contact mediated by TMED9 and SEC12 is required for autophagosome biogenesis
Under stress, the endomembrane system undergoes reorganization to support
autophagosome biogenesis, which is a central step in autophagy. How the endomembrane …
autophagosome biogenesis, which is a central step in autophagy. How the endomembrane …
ER-phagy mediates selective degradation of endoplasmic reticulum independently of the core autophagy machinery
Selective autophagy of damaged or redundant organelles is an important mechanism for
maintaining cell homeostasis. We found previously that endoplasmic reticulum (ER) stress in …
maintaining cell homeostasis. We found previously that endoplasmic reticulum (ER) stress in …
[HTML][HTML] Two distinct mechanisms target the autophagy-related E3 complex to the pre-autophagosomal structure
K Harada, T Kotani, H Kirisako, M Sakoh-Nakatogawa… - elife, 2019 - elifesciences.org
In autophagy, Atg proteins organize the pre-autophagosomal structure (PAS) to initiate
autophagosome formation. Previous studies in yeast revealed that the autophagy-related E3 …
autophagosome formation. Previous studies in yeast revealed that the autophagy-related E3 …
Remodeling of ER‐exit sites initiates a membrane supply pathway for autophagosome biogenesis
Autophagosomes are double‐membrane vesicles generated during autophagy. Biogenesis
of the autophagosome requires membrane acquisition from intracellular compartments, the …
of the autophagosome requires membrane acquisition from intracellular compartments, the …