What Are the Roles of Oligodendrocyte Precursor Cells in Normal and Pathologic Conditions?

E Benarroch - Neurology, 2023 - AAN Enterprises
Adult oligodendrocyte precursor (or progenitor) cells (OPCs) are the most proliferative cells
in the CNS and constitute approximately 10% of cells in the human brain. 1, 2 Whereas their …

Many roles for oligodendrocyte precursor cells in physiology and pathology

A Nishiyama, DR Serwanski, F Pfeiffer - Neuropathology, 2021 - Wiley Online Library
Oligodendrocyte precursor cells (OPCs) are a fourth resident glial cell population in the
mammalian central nervous system. They are evenly distributed throughout the gray and …

The oligodendrocyte precursor cell in health and disease

JM Levine, R Reynolds, JW Fawcett - Trends in neurosciences, 2001 - cell.com
Adult oligodendrocyte precursor cells (OPCs) make up around 5–8% of the glial cell
population in the CNS. Their function in the undamaged CNS is largely unknown, but their …

A matter of state: diversity in oligodendrocyte lineage cells

Y Kamen, H Pivonkova, KA Evans… - The …, 2022 - journals.sagepub.com
Oligodendrocyte precursor cells (OPCs) give rise to oligodendrocytes which myelinate
axons in the central nervous system. Although classically thought to be a homogeneous …

Heterogeneity of oligodendrocyte progenitor cells in adult human brain

SY Leong, VTS Rao, JM Bin, P Gris… - Annals of clinical …, 2014 - Wiley Online Library
Objective Remyelination in multiple sclerosis has been attributed to the presence of
oligodendrocyte progenitor cells (OPC s) in brain parenchyma. However, the precise identity …

Cell of all trades: oligodendrocyte precursor cells in synaptic, vascular, and immune function

LA Akay, AH Effenberger, LH Tsai - Genes & development, 2021 - genesdev.cshlp.org
Oligodendrocyte precursor cells (OPCs) are not merely a transitory progenitor cell type, but
rather a distinct and heterogeneous population of glia with various functions in the …

Oligodendrocyte progenitors: adult stem cells of the central nervous system?

AH Crawford, JH Stockley, RB Tripathi… - Experimental …, 2014 - Elsevier
Oligodendrocyte progenitors (OPs) are a major proliferating cell population within the adult
CNS. In response to myelin loss or increasing demand, OPs have the capacity to …

Oligodendrocytes in development, myelin generation and beyond

S Kuhn, L Gritti, D Crooks, Y Dombrowski - Cells, 2019 - mdpi.com
Oligodendrocytes are the myelinating cells of the central nervous system (CNS) that are
generated from oligodendrocyte progenitor cells (OPC). OPC are distributed throughout the …

Myelination-independent functions of oligodendrocyte precursor cells in health and disease

Y Xiao, T Czopka - Nature Neuroscience, 2023 - nature.com
Oligodendrocyte precursor cells (OPCs) are a population of tissue-resident glial cells found
throughout the CNS, constituting approximately 5% of all CNS cells and persisting from …

Oligodendrocyte progenitor cells become regionally diverse and heterogeneous with age

SO Spitzer, S Sitnikov, Y Kamen, KA Evans… - Neuron, 2019 - cell.com
Oligodendrocyte progenitor cells (OPCs), which differentiate into myelinating
oligodendrocytes during CNS development, are the main proliferative cells in the adult …