Indigenous peoples of the Americas are proficient in botanical medicine. KCNQ family
voltage-gated potassium (Kv) channels are sensitive to a variety of ligands, including plant …

Botanical folk medicines have been used throughout human history to treat common
disorders such as hypertension, often with unknown underlying mechanisms. Here, we …

Since prehistory, human species have depended on plants for both food and medicine.
Even in countries with ready access to modern medicines, alternative treatments are still …

Tree and shrub barks have been used as folk medicine by numerous cultures across the
globe for millennia, for a variety of indications, including as vasorelaxants and …

Many commonly consumed plants are used as folk medicines, often with unclear molecular
mechanisms. Recent studies uncovered the ubiquitous and influential KCNQ family of …

Voltage-gated potassium (Kv) channels in the KCNQ (Kv7) family are essential features of a
broad range of excitable and non-excitable cell types and are found in organisms ranging …

Voltage-gated potassium (Kv) channels in the KCNQ subfamily serve essential roles in the
nervous system, heart, muscle and epithelia. Different heteromeric KCNQ complexes likely …

Methods: We applied electrophysiology, myography, mass spectrometry and in silico
docking to determine effects and their underlying molecular mechanisms of tea and its …

Neuronal voltage-gated KCNQ (Kv7) channels, expressed centrally and peripherally,
mediate low-threshold and non-inactivating M-currents responsible for the control of tonic …

Kv7. 2–7.5 voltage-gated potassium channels (KCNQ2–5) are associated with M-current
and known to distribute in the nociceptive sensory pathway (eg, dorsal root ganglia and …