Establishment of an in vivo simulating co‐culture assay platform for genotoxicity of multi‐walled carbon nanotubes

E Fukai, H Sato, M Watanabe, D Nakae… - Cancer …, 2018 - Wiley Online Library
Engineered nanomaterials (ENM) are now used in a wide variety of fields, and, thus, their
safety should urgently be assessed and secured. It has been suggested that inflammatory …

[HTML][HTML] In vivo genotoxicity assessment of a multiwalled carbon nanotube in a mouse ex vivo culture

K Horibata, H Takasawa, M Hojo, Y Taquahashi… - Genes and …, 2022 - Springer
Abstract Background Multiwalled carbon nanotubes (MWCNTs) are suspected lung
carcinogens because their shape and size are similar to asbestos. Various MWCNT types …

Genotoxicity of multi-walled carbon nanotubes in both in vitro and in vivo assay systems

T Kato, Y Totsuka, K Ishino, Y Matsumoto, Y Tada… - …, 2013 - Taylor & Francis
The genotoxic effects of multi-walled carbon nanotubes (MWCNTs) were examined by using
in vitro and in vivo assays. MWCNTs significantly induced micronuclei in A549 cells and …

[HTML][HTML] Multi-walled carbon nanotube-induced genotoxic, inflammatory and pro-fibrotic responses in mice: Investigating the mechanisms of pulmonary …

L Rahman, NR Jacobsen, SA Aziz, D Wu… - … /Genetic Toxicology and …, 2017 - Elsevier
Abstract The International Agency for Research on Cancer has classified one type of multi-
walled carbon nanotubes (MWCNTs) as possibly carcinogenic to humans. However, the …

Multi-walled carbon nanotube-induced gene expression in vitro: concordance with in vivo studies

BN Snyder-Talkington, C Dong, X Zhao, J Dymacek… - Toxicology, 2015 - Elsevier
There is a current interest in reducing the in vivo toxicity testing of nanomaterials in animals
by increasing toxicity testing using in vitro cellular assays; however, toxicological results are …

Multi‐walled carbon nanotubes induce cytotoxicity and genotoxicity in human lung epithelial cells

D Cavallo, C Fanizza, CL Ursini… - Journal of Applied …, 2012 - Wiley Online Library
The increasing use of nanomaterials in consumer products highlights the importance of
understanding their potential toxic effects. We evaluated cytotoxic and genotoxic/oxidative …

Characterization of genotoxic response to 15 multiwalled carbon nanotubes with variable physicochemical properties including surface functionalizations in the FE 1 …

P Jackson, K Kling, KA Jensen… - Environmental and …, 2015 - Wiley Online Library
Carbon nanotubes vary greatly in physicochemical properties. We compared cytotoxic and
genotoxic response to 15 multiwalled carbon nanotubes (MWCNT) with varying …

Clastogenic and aneugenic effects of multi-wall carbon nanotubes in epithelial cells

J Muller, I Decordier, PH Hoet, N Lombaert… - …, 2008 - academic.oup.com
Abstract Information on the toxicity of carbon nanotubes is still fragmentary but indicates that
these particles can induce adverse effects. We previously demonstrated in rats that, when …

[HTML][HTML] Mitsui-7, heat-treated, and nitrogen-doped multi-walled carbon nanotubes elicit genotoxicity in human lung epithelial cells

KJ Siegrist, SH Reynolds, DW Porter… - Particle and Fibre …, 2019 - Springer
Background The unique physicochemical properties of multi-walled carbon nanotubes
(MWCNT) have led to many industrial applications. Due to their low density and small size …

Comparative cyto-genotoxicity assessment of functionalized and pristine multiwalled carbon nanotubes on human lung epithelial cells

CL Ursini, D Cavallo, AM Fresegna, A Ciervo… - Toxicology in Vitro, 2012 - Elsevier
Chemical functionalization extends CNT applications conferring them new functions, but
could modify their toxicity. We compared cytotoxicity and genotoxic/oxidative effects of–OH …