Stunted microbiota and opportunistic pathogen colonization in caesarean-section birth

Y Shao, SC Forster, E Tsaliki, K Vervier, A Strang… - Nature, 2019 - nature.com
Immediately after birth, newborn babies experience rapid colonization by microorganisms
from their mothers and the surrounding environment. Diseases in childhood and later in life …

Multi-kingdom ecological drivers of microbiota assembly in preterm infants

C Rao, KZ Coyte, W Bainter, RS Geha, CR Martin… - Nature, 2021 - nature.com
The gut microbiota of preterm infants develops predictably,,,,,–, with pioneer species
colonizing the gut after birth, followed by an ordered succession of microorganisms. The gut …

Impact of delivery mode-associated gut microbiota dynamics on health in the first year of life

M Reyman, MA van Houten, D van Baarle… - Nature …, 2019 - nature.com
The early-life microbiome appears to be affected by mode of delivery, but this effect may
depend on intrapartum antibiotic exposure. Here, we assess the effect of delivery mode on …

Viable bacterial colonization is highly limited in the human intestine in utero

E Rackaityte, J Halkias, EM Fukui, VF Mendoza… - Nature medicine, 2020 - nature.com
Mucosal immunity develops in the human fetal intestine by 11–14 weeks of gestation, yet
whether viable microbes exist in utero and interact with the intestinal immune system is …

Maturation of the infant microbiome community structure and function across multiple body sites and in relation to mode of delivery

DM Chu, J Ma, AL Prince, KM Antony, MD Seferovic… - Nature medicine, 2017 - nature.com
Human microbial communities are characterized by their taxonomic, metagenomic and
metabolic diversity, which varies by distinct body sites and influences human physiology …

Delivery mode affects stability of early infant gut microbiota

CM Mitchell, C Mazzoni, L Hogstrom, A Bryant… - Cell Reports …, 2020 - cell.com
Mode of delivery strongly influences the early infant gut microbiome. Children born by
cesarean section (C-section) lack Bacteroides species until 6–18 months of age. One …

Early life colonization of the human gut: microbes matter everywhere

K Korpela, WM de Vos - Current opinion in microbiology, 2018 - Elsevier
Highlights•The intestinal microbiota follows a common successional pattern in early
life.•Particular bacterial taxa are mainly transmitted from the mother to the infant after …

Partial restoration of the microbiota of cesarean-born infants via vaginal microbial transfer

MG Dominguez-Bello, KM De Jesus-Laboy, N Shen… - Nature medicine, 2016 - nature.com
Exposure of newborns to the maternal vaginal microbiota is interrupted with cesarean
birthing. Babies delivered by cesarean section (C-section) acquire a microbiota that differs …

The maternal microbiota drives early postnatal innate immune development

M Gomez de Agüero, SC Ganal-Vonarburg, T Fuhrer… - Science, 2016 - science.org
Postnatal colonization of the body with microbes is assumed to be the main stimulus to
postnatal immune development. By transiently colonizing pregnant female mice, we show …

Biphasic assembly of the murine intestinal microbiota during early development

IG Pantoja-Feliciano, JC Clemente… - The ISME …, 2013 - academic.oup.com
The birth canal provides mammals with a primary maternal inoculum, which develops into
distinctive body site-specific microbial communities post-natally. We characterized the distal …