The hypoxia-inducible factors (HIF) are transcription factors that activate the adaptive
hypoxic response when oxygen levels are low. The HIF transcriptional program increases …

The hypoxia-inducible factor (HIF)-1α and HIF-2α are closely related, key transcriptional
regulators of the hypoxic response, countering a low oxygen situation with the up-regulation …

Hypoxia is an inadequate oxygen supply to tissues and cells, which can restrict their
function. The hypoxic response is primarily mediated by the hypoxia-inducible transcription …

The adaptive response to hypoxia involves the transcriptional induction of three transcription
factors called hypoxia inducible factor alpha 1, 2 and 3 (HIF-1α, HIF-2α, and HIF-3α) which …

Hypoxia-inducible factor (HIF) is a sequence-specific DNA-binding protein that can promote
or repress the transcription of a broad range of genes that are involved in maintaining …

Cells induce the hypoxia responses to adapt to the environment when organisms are
exposed to a low oxygen environment. The hypoxia response leads to the activation of …

Oxygen-dependent proteolysis is the primary means of regulating the hypoxia-inducible
factor (HIF) family of transcription factors. The alpha-subunit of HIF factor 1 (HIF-1) contains …

Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription factor that is critical for
hypoxic induction of a number of physiologically important genes. We present evidence that …

Many molecular and physiological responses to hypoxia in mammals are controlled by the
transcription factors Hypoxia-Inducible Factor-1α (HIF-1α) and HIF-2α. Their ability to …

The heterodimeric hypoxia‐inducible factor (HIF)‐1 is a master transcriptional regulator of
oxygen homeostasis and a possible target for gene therapy of ischemic disease. Although …