[HTML][HTML] Real-world evidence of levofloxacin prophylaxis in elderly patients with newly diagnosed multiple myeloma who received bortezomib, melphalan, and …

SI Kim, SH Jung, HY Yhim, JC Jo, GY Song, M Kim… - Blood …, 2022 - ncbi.nlm.nih.gov
Background Although survival outcomes of multiple myeloma (MM) have improved with the
development of new and effective agents, infection remains the major cause of morbidity …

Effect of levofloxacin prophylaxis for prevention of severe infections in multiple myeloma patients receiving bortezomib-containing regimens

SH Jung, SJ Kang, HC Jang, JS Ahn, DH Yang… - International journal of …, 2014 - Springer
Fluoroquinolone is recommended as a prophylactic antibiotic for high-risk patients with
profound neutropenia. We previously reported that multiple myeloma (MM) patients who …

Levofloxacin prophylaxis in patients with newly diagnosed myeloma (TEAMM): a multicentre, double-blind, placebo-controlled, randomised, phase 3 trial

MT Drayson, S Bowcock, T Planche, G Iqbal… - The Lancet …, 2019 - thelancet.com
Background Myeloma causes profound immunodeficiency and recurrent, serious infections.
Around 5500 new cases of myeloma are diagnosed per year in the UK, and a quarter of …

Oral antibiotic prophylaxis of early infection in multiple myeloma: a URCC/ECOG randomized phase III study

DH Vesole, MM Oken, C Heckler, PR Greipp, MS Katz… - Leukemia, 2012 - nature.com
Multiple myeloma (MM) is a malignancy of clonal plasma cells, resulting in an increased
production of ineffective immunoglobulins with suppression of non-involved …

[HTML][HTML] Oral Antibiotic Prophylaxis of Early Infection In Multiple Myeloma: A URCC/ECOG Phase III Study

DH Vesole, MM Oken, C Heckler, PR Greipp, MS Katz… - Blood, 2010 - Elsevier
Abstract Abstract 3017 Introduction: Multiple myeloma (MM) is a malignancy of clonal
plasma cells with resulting in an increase production of ineffective immunoglobulins with …

Antibiotic prophylaxis for patients with newly diagnosed multiple myeloma: Systematic review and meta‐analysis

GR Mohyuddin, M Aziz, B McClune… - European journal of …, 2020 - Wiley Online Library
Objective Ascertain the benefit of prophylactic antibiotics for patients with newly diagnosed
multiple myeloma (MM), given that clinical trials evaluating this have had conflicting results …

[HTML][HTML] Risk of Early Severe Infections in Newly Diagnosed Multiple Myeloma Patients Treated with Novel Agents: A Pooled Analysis

F Bonello, M D'Agostino, M Offidani, MT Petrucci… - Blood, 2020 - Elsevier
Background. Infections represent a major cause of toxicity in newly diagnosed multiple
myeloma (NDMM) patients, and their incidence is higher during the first 4 months of therapy …

[HTML][HTML] Tackling early morbidity and mortality in myeloma (TEAMM): assessing the benefit of antibiotic prophylaxis and its effect on healthcare associated infections in …

MT Drayson, S Bowcock, T Planche, G Iqbal, J Wood… - Blood, 2017 - Elsevier
Abstract Background TEAMM (Tackling EArly Morbidity and Mortality in Myeloma) was a
randomised, double-blind, placebo-controlled multi-centre phase III clinical trial assessing …

Stratifying risk of infection and response to therapy in patients with myeloma: a prognostic study

IJ Chicca, JLJ Heaney, G Iqbal, JA Dunn… - Efficacy and …, 2020 - discovery.ucl.ac.uk
Background: Multiple myeloma is a cancer of plasma cells that is associated with severe
immunodeficiency and increased numbers of bacterial infections. The Tackling Early …

[HTML][HTML] Infection complications in 476 patients with newly diagnosed multiple myeloma treated with lenalidomide or bortezomib combinations

M Offidani, L Corvatta, S Bringhen, S Gentili, F Gay… - Blood, 2015 - Elsevier
Introduction. Multiple myeloma (MM) represents a population with an increased risk of
developing infection up to 10-fold if compared with controls. Moreover, patients treated with …