Technological and methodological advances are enabling researchers to unravel the
genetics of ALS. Both causal mutations and genetic modifiers are viable therapeutic targets …

The scientific landscape surrounding amyotrophic lateral sclerosis (ALS) continues to shift
as the number of genes associated with the disease risk and pathogenesis, and the cellular …

Abstract Purpose of Review Amyotrophic lateral sclerosis and frontotemporal dementia (ALS-
FTD) spectrum disorder is a rare fatal disease with strong genetic influences. The …

Abstract Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease that has
significant overlap with frontotemporal dementia (FTD). Mutations in specific genes have …

The field of ALS continues to develop rapidly with multiple disease gene discoveries per
year. The relevance of these findings for genetic counseling and diagnosis is obvious. With …

Genetic insights into the pathophysiology of amyotrophic lateral sclerosis (ALS) are
untangling the clinical heterogeneity that may contribute to poor clinical trial outcomes and …

Amyotrophic lateral sclerosis (ALS) is a progressive, noncurable neurodegenerative
disorder of the upper and lower motor neurons causing weakness and death within a few …

Amyotrophic lateral sclerosis (ALS) is the most common type of motor neuron disease
whose causes are unclear. The first ALS gene associated with the autosomal dominant form …

Familial amyotrophic lateral sclerosis (ALS) accounts for 10% of all ALS cases; 12–23% are
associated with mutations in the Cu/Zn superoxide dismutase gene (SOD1). All ALS-linked …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the
degeneration of motor neurons in the brain and spinal cord. The causes of ALS are not fully …