Background Temporary disruption of the blood-brain barrier (BBB) using pulsed ultrasound
leads to the clearance of both amyloid and tau from the brain, increased neurogenesis, and …

OBJECTIVE MRI-guided low-intensity focused ultrasound (FUS) has been shown to
reversibly open the blood-brain barrier (BBB), with the potential to deliver therapeutic agents …

Magnetic resonance-guided focused ultrasound in combination with intravenously injected
microbubbles has been shown to transiently open the blood–brain barrier, and reduce beta …

The blood–brain barrier (BBB) limits therapeutic delivery in Alzheimer's disease (AD) and
other neurological disorders. Animal models have demonstrated safe BBB opening and …

Previous studies have demonstrated that temporarily increasing the permeability of the
blood-brain barrier using focused ultrasound can reduce β-amyloid plaque load and …

Antiamyloid antibodies have been used to reduce cerebral amyloid-beta (Aβ) load in
patients with Alzheimer's disease. We applied focused ultrasound with each of six monthly …

Rationale: Ultrasound-mediated opening of the Blood-Brain Barrier (BBB) has shown
exciting potential for the treatment of Alzheimer's disease (AD). Studies in transgenic mouse …

Alzheimer's Disease (AD) is a neurodegenerative disorder characterized by the
accumulation of amyloid plaques and hyperphosphorylated tau in the brain. Currently …

Noninvasive, targeted drug delivery to the brain can be achieved using transcranial focused
ultrasound (FUS), which transiently increases the permeability of the blood–brain barrier …

The neuropathological hallmarks of Alzheimer's disease include amyloid plaques and
neurofibrillary tangles. Tau pathology correlates well with impaired neuronal activity and …