Understanding the mechanisms underlying carcinogenesis provides insights that are
necessary for the development of therapeutic strategies to prevent cancer …

Understanding the mechanisms underlying carcinogenesis provides insights that are
necessary for the development of therapeutic strategies to prevent cancer …

Cyclooxygenase-2 (COX-2) is being intensively evaluated as a pharmacologic target for
both the prevention and treatment of cancer. Aberrant COX-2 expression was initially …

Carcinogenesis results from the long-term accumulation of genetic and epigenetic
aberrations at the molecular level, which are under constant selection pressure for growth …

Head and neck squamous cell carcinoma is a well-known model for chemoprevention
studies because of its field cancerization effect, its multistep carcinogenesis process, and the …

Abstract Cyclooxygenase2 (COX-2), an inducible prostaglandin G/H synthase, is
overexpressed in several human cancers. Here, the potential utility of selective COX-2 …

Expression of cyclooxygenase-2 (COX-2) has been reported to be elevated in human
colorectal adenocarcinoma and other tumors, including those of breast, cervical, prostate …

An expanding body of evidence indicates that downregulation of the cy-clooxygenases (Cox-
1 and Cox-2) will be an important strategy for preventing cancer because cyclooxygenases …

The existing epidemiologic literature was comprehensively reviewed to retrieve all
epidemiologic studies (case control and cohort studies) that examined exposure to …

Several lines of evidence suggest that cyclooxygenase-2 (COX-2) is a rational target for
anticancer therapy. Epidemiological studies have shown that use of nonsteroidal anti …