In the noisy cellular environment, gene products are subject to inherent random fluctuations
in copy numbers over time. How cells ensure precision in the timing of key intracellular …

Expression of many genes varies as a cell transitions through different cell-cycle stages.
How coupling between stochastic expression and cell cycle impacts cell-to-cell variability …

How the noisy expression of regulatory proteins affects timing of intracellular events is an
intriguing fundamental problem that influences diverse cellular processes. Here we use the …

Timing is essential for many cellular processes, from cellular responses to external stimuli to
the cell cycle and circadian clocks. Many of these processes are based on gene expression …

Gene regulatory networks are largely responsible for cellular decision-making. These
networks sense diverse external signals and respond by adjusting gene expression …

Inside individual cells, expression of genes is stochastic across organisms ranging from
bacterial to human cells. A ubiquitous feature of stochastic expression is burst-like synthesis …

Experiments in recent years have vividly demonstrated that gene expression can be highly
stochastic. How protein concentration fluctuations affect the growth rate of a population of …

We present an analytical framework describing the steady-state distribution of protein
concentration in live cells, considering that protein production occurs in random bursts with …

The stochasticity of gene expression presents significant challenges to the modeling of
genetic networks. A two-state model describing promoter switching, transcription, and …

The small number of reactant molecules involved in gene regulation can lead to significant
fluctuations in intracellular mRNA and protein concentrations, and there have been …