The absorption of orally administered drug products is a complex, dynamic process,
dependant on a range of biopharmaceutical properties; notably the aqueous solubility of a …

The main objective of this review is to discuss recent advancements in the overall
investigation and in vivo prediction of drug absorption. The intestinal permeability of an …

The clinical development of new drugs is often terminated because of unfavourable
pharmacokinetic properties such as poor intestinal absorption after oral administration …

Oral drug absorption is the movement of the drug from its site of administration,
gastrointestinal (GI), into the bloodstream. The oral absorption of the drug in solid dosage …

Highlights•It is of primary importance to obtain relevant models in drug
discovery.•Physiology and biology of the oral route is complex to model.•In silico models …

The majority (84%) of the 50 most-sold pharmaceutical products in the US and European
markets are given orally. The dominating role of this route in drug therapy is a consequence …

The oral route is the preferred way of dosing, because this is the easiest and most
convenient way of noninvasive administration. Most drug substances that are applied orally …

Intestinal absorption in human is routinely predicted in drug discovery using in vitro assays
such as permeability in the Madin-Darby canine kidney cell line. In silico models trained on …

The most convenient route of drug administration is peroral. To reach their target, drug
molecules must be absorbed from the gastrointestinal tract and enter the systemic circulation …

Abstract□ This review focuses on permeability measurements in humans, briefly discussing
different perfusion techniques, the relevance of human P eff values, and various aspects of …