Tissue injury is associated with sensitization of nociceptors and subsequent changes in the
excitability of central (spinal) neurons, termed central sensitization. Nociceptor sensitization …

Publisher Summary Hyperalgesia and allodynia often aggravate pain for variable periods
after trauma, surgery, and inflammation. Pain that is induced by normally nonpainful stimuli …

A rat population with variable responses to nerve injury indicated that activation of
descending inhibition with a spinal noradrenergic component prevents development of …

The highly disagreeable sensation of pain results from an extraordinarily complex and
interactive series of mechanisms integrated at all levels of the neuroaxis, from the periphery …

Although injury-induced afferent discharge declines significantly over time, experimental
neuropathic pain persists unchanged for long periods. These observations suggest that …

Tissue injury produces hyperalgesia not only in the injured area (primary hyperalgesia) but
also outside of it (secondary hyperalgesia). In the present investigation, the submodality …

The rostral ventromedial medulla (RVM) has recently received considerable attention in
efforts to understand mechanisms of hyperalgesia and persistent pain states. Three classes …

Nerve injury can lead to mechanical hypersensitivity in both humans and animal models,
such that innocuous touch produces pain. Recent functional studies have demonstrated a …

Behavioral models indicate that persistent small afferent input, as generated by tissue injury,
results in a hyperalgesia at the site of injury and a tactile allodynia in areas adjacent to the …

The rostral ventromedial medulla (RVM) is involved in facilitation of spinal nociceptive
processing and generation of hyperalgesia in inflammatory and neuropathic pain models …